Last reviewed · How we verify
Dysport® (abobotulinumtoxinA)
Dysport® (abobotulinumtoxinA) is a Botulinum toxin Small molecule drug developed by Seoul National University Hospital. It is currently FDA-approved for Cervical dystonia (spasmodic torticollis), Blepharospasm, Hemifacial spasm. Also known as: Dysport® (abobotulinumtoxinA)injection, AbobotulinumtoxinA, Clostridium botulinum type toxin A toxin-haemagglutinin complex.
Dysport blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.
Dysport blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia (spasmodic torticollis), Blepharospasm, Hemifacial spasm.
At a glance
| Generic name | Dysport® (abobotulinumtoxinA) |
|---|---|
| Also known as | Dysport® (abobotulinumtoxinA)injection, AbobotulinumtoxinA, Clostridium botulinum type toxin A toxin-haemagglutinin complex |
| Sponsor | Seoul National University Hospital |
| Drug class | Botulinum toxin |
| Target | SNAP-25 (synaptosome-associated protein of 25 kDa) |
| Modality | Small molecule |
| Therapeutic area | Neurology, Dermatology, Aesthetics |
| Phase | FDA-approved |
Mechanism of action
AbobotulinumtoxinA is a botulinum toxin serotype A that irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle fusion and release. This prevents neuromuscular transmission, leading to flaccid paralysis of injected muscles. The effect is temporary, lasting 3–4 months, after which nerve terminals regenerate and muscle function returns.
Approved indications
- Cervical dystonia (spasmodic torticollis)
- Blepharospasm
- Hemifacial spasm
- Glabellar lines (dynamic wrinkles)
- Lateral canthal lines (crow's feet)
- Forehead lines
- Post-stroke upper limb spasticity
Common side effects
- Injection site pain or bruising
- Headache
- Muscle weakness (localized)
- Ptosis (eyelid drooping)
- Dry mouth
- Neck pain
- Antibody formation (neutralizing)
Key clinical trials
- Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome (PHASE2)
- A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica Products (PHASE4)
- Prospective, Non-interventional Study Assessing Periorbital Rejuvenation Procedure
- A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine (PHASE3)
- A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine (PHASE3)
- Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial (PHASE4)
- A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Episodic Migraine in Adults (PHASE3)
- A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dysport® (abobotulinumtoxinA) CI brief — competitive landscape report
- Dysport® (abobotulinumtoxinA) updates RSS · CI watch RSS
- Seoul National University Hospital portfolio CI
Frequently asked questions about Dysport® (abobotulinumtoxinA)
What is Dysport® (abobotulinumtoxinA)?
How does Dysport® (abobotulinumtoxinA) work?
What is Dysport® (abobotulinumtoxinA) used for?
Who makes Dysport® (abobotulinumtoxinA)?
Is Dysport® (abobotulinumtoxinA) also known as anything else?
What drug class is Dysport® (abobotulinumtoxinA) in?
What development phase is Dysport® (abobotulinumtoxinA) in?
What are the side effects of Dysport® (abobotulinumtoxinA)?
What does Dysport® (abobotulinumtoxinA) target?
Related
- Drug class: All Botulinum toxin drugs
- Target: All drugs targeting SNAP-25 (synaptosome-associated protein of 25 kDa)
- Manufacturer: Seoul National University Hospital — full pipeline
- Therapeutic area: All drugs in Neurology, Dermatology, Aesthetics
- Indication: Drugs for Cervical dystonia (spasmodic torticollis)
- Indication: Drugs for Blepharospasm
- Indication: Drugs for Hemifacial spasm
- Also known as: Dysport® (abobotulinumtoxinA)injection, AbobotulinumtoxinA, Clostridium botulinum type toxin A toxin-haemagglutinin complex
- Compare: Dysport® (abobotulinumtoxinA) vs similar drugs
- Pricing: Dysport® (abobotulinumtoxinA) cost, discount & access