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Dynastat (original Parecoxib)

University of Malaya · FDA-approved active Small molecule

Dynastat (original Parecoxib) is a Selective COX-2 inhibitor (coxib) Small molecule drug developed by University of Malaya. It is currently FDA-approved for Acute postoperative pain, Perioperative pain management.

Parecoxib selectively inhibits cyclooxygenase-2 (COX-2) to reduce prostaglandin production and provide anti-inflammatory and analgesic effects.

Parecoxib selectively inhibits cyclooxygenase-2 (COX-2) to reduce prostaglandin production and provide anti-inflammatory and analgesic effects. Used for Acute postoperative pain, Perioperative pain management.

At a glance

Generic nameDynastat (original Parecoxib)
SponsorUniversity of Malaya
Drug classSelective COX-2 inhibitor (coxib)
TargetCOX-2 (Cyclooxygenase-2)
ModalitySmall molecule
Therapeutic areaPain Management / Rheumatology
PhaseFDA-approved

Mechanism of action

As a selective COX-2 inhibitor, parecoxib blocks the enzyme responsible for producing inflammatory prostaglandins while sparing COX-1, which protects the gastrointestinal tract. This selective inhibition provides pain relief and reduces inflammation with a lower risk of GI side effects compared to non-selective NSAIDs. Parecoxib is the intravenous prodrug form of valdecoxib.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Dynastat (original Parecoxib)

What is Dynastat (original Parecoxib)?

Dynastat (original Parecoxib) is a Selective COX-2 inhibitor (coxib) drug developed by University of Malaya, indicated for Acute postoperative pain, Perioperative pain management.

How does Dynastat (original Parecoxib) work?

Parecoxib selectively inhibits cyclooxygenase-2 (COX-2) to reduce prostaglandin production and provide anti-inflammatory and analgesic effects.

What is Dynastat (original Parecoxib) used for?

Dynastat (original Parecoxib) is indicated for Acute postoperative pain, Perioperative pain management.

Who makes Dynastat (original Parecoxib)?

Dynastat (original Parecoxib) is developed and marketed by University of Malaya (see full University of Malaya pipeline at /company/university-of-malaya).

What drug class is Dynastat (original Parecoxib) in?

Dynastat (original Parecoxib) belongs to the Selective COX-2 inhibitor (coxib) class. See all Selective COX-2 inhibitor (coxib) drugs at /class/selective-cox-2-inhibitor-coxib.

What development phase is Dynastat (original Parecoxib) in?

Dynastat (original Parecoxib) is FDA-approved (marketed).

What are the side effects of Dynastat (original Parecoxib)?

Common side effects of Dynastat (original Parecoxib) include Hypertension, Cardiovascular events, Nausea, Headache.

What does Dynastat (original Parecoxib) target?

Dynastat (original Parecoxib) targets COX-2 (Cyclooxygenase-2) and is a Selective COX-2 inhibitor (coxib).

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