{"id":"dynastat-original-parecoxib","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Cardiovascular events"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1206690","moleculeType":"Small molecule","molecularWeight":"370.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a selective COX-2 inhibitor, parecoxib blocks the enzyme responsible for producing inflammatory prostaglandins while sparing COX-1, which protects the gastrointestinal tract. This selective inhibition provides pain relief and reduces inflammation with a lower risk of GI side effects compared to non-selective NSAIDs. Parecoxib is the intravenous prodrug form of valdecoxib.","oneSentence":"Parecoxib selectively inhibits cyclooxygenase-2 (COX-2) to reduce prostaglandin production and provide anti-inflammatory and analgesic effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:35:46.988Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute postoperative pain"},{"name":"Perioperative pain management"}]},"trialDetails":[{"nctId":"NCT07154446","phase":"PHASE4","title":"Study Comparing Dynastat and Parestat Pain Relief Medications for Patients After Breast Surgery","status":"NOT_YET_RECRUITING","sponsor":"University of Malaya","startDate":"2025-10-01","conditions":"Breast Exicision Biopsy","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Dynastat (original Parecoxib)","genericName":"Dynastat (original Parecoxib)","companyName":"University of Malaya","companyId":"university-of-malaya","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Parecoxib selectively inhibits cyclooxygenase-2 (COX-2) to reduce prostaglandin production and provide anti-inflammatory and analgesic effects. Used for Acute postoperative pain, Perioperative pain management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}