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dl-3-n-butylphthalide (NBP)
DL-3-n-butylphthalide (NBP) is a small molecule that acts as a vasodilator and neuroprotective agent.
DL-3-n-butylphthalide (NBP) is a small molecule that acts as a vasodilator and neuroprotective agent. Used for Ischemic stroke, Cerebral ischemia.
At a glance
| Generic name | dl-3-n-butylphthalide (NBP) |
|---|---|
| Sponsor | yuanli Zhao |
| Drug class | vasodilator |
| Modality | Small molecule |
| Therapeutic area | Cerebrovascular Disease |
| Phase | Phase 3 |
Mechanism of action
NBP has been shown to improve blood flow and reduce inflammation in the brain, which may help to prevent or treat conditions such as stroke and cerebral ischemia. Its exact mechanism of action is not fully understood, but it is thought to involve the modulation of various signaling pathways involved in vascular function and neuroprotection.
Approved indications
- Ischemic stroke
- Cerebral ischemia
Common side effects
- Headache
- Dizziness
- Nausea
Key clinical trials
- Butylphthalide for Cognitive Impairment in Elderly Patients With Focal Epilepsy (PHASE4)
- Effects of DL-3-n-butylphthalide on Chemotherapy-Induced Cognitive Impairment (PHASE4)
- Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER) (PHASE3)
- Dl-3-n-butylphthalide and Cerebrolysin Treatment in Acute Ischemic Stroke (PHASE1, PHASE2)
- DL-3-n-butylphthalide Treatment in Patients With Mild to Moderate Alzheimer's Disease Already Receiving Donepezil
- NBP in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular Events (PHASE3)
- The Efficacy of DL-NBP in Patients With Mild Subcortical Ischemic Vascular Dementia (NA)
- The Efficacy of Butylphthalide Soft Capsules in Patents With VCIND (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- dl-3-n-butylphthalide (NBP) CI brief — competitive landscape report
- dl-3-n-butylphthalide (NBP) updates RSS · CI watch RSS
- yuanli Zhao portfolio CI