{"id":"dl-3-n-butylphthalide-nbp","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL248594","moleculeType":"Small molecule","molecularWeight":"190.24"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"NBP has been shown to improve blood flow and reduce inflammation in the brain, which may help to prevent or treat conditions such as stroke and cerebral ischemia. Its exact mechanism of action is not fully understood, but it is thought to involve the modulation of various signaling pathways involved in vascular function and neuroprotection.","oneSentence":"DL-3-n-butylphthalide (NBP) is a small molecule that acts as a vasodilator and neuroprotective agent.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:36.928Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ischemic stroke"},{"name":"Cerebral ischemia"}]},"trialDetails":[{"nctId":"NCT07193277","phase":"PHASE4","title":"Butylphthalide for Cognitive Impairment in Elderly Patients With Focal Epilepsy","status":"RECRUITING","sponsor":"First Affiliated Hospital of Wenzhou Medical University","startDate":"2025-09-01","conditions":"Focal Epilepsy, Cognitive Impairment","enrollment":220},{"nctId":"NCT06508671","phase":"PHASE4","title":"Effects of DL-3-n-butylphthalide on Chemotherapy-Induced Cognitive Impairment","status":"NOT_YET_RECRUITING","sponsor":"First Hospital of China Medical University","startDate":"2024-07","conditions":"Chemotherapy-Related Cognitive Impairment, DL-3-n-butylphthalide","enrollment":100},{"nctId":"NCT05976152","phase":"PHASE3","title":"Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER)","status":"RECRUITING","sponsor":"Fudan University","startDate":"2024-04","conditions":"Stroke, Post-stroke Cognitive Impairment (PSCI)","enrollment":3200},{"nctId":"NCT02149875","phase":"PHASE1, PHASE2","title":"Dl-3-n-butylphthalide and Cerebrolysin Treatment in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Shanghai 6th People's Hospital","startDate":"2010-01","conditions":"Acute Cerebral Stroke Within 12 Hours for the First Time","enrollment":84},{"nctId":"NCT02711683","phase":"","title":"DL-3-n-butylphthalide Treatment in Patients With Mild to Moderate Alzheimer's Disease Already Receiving Donepezil","status":"COMPLETED","sponsor":"First Affiliated Hospital Xi'an Jiaotong University","startDate":"2016-03","conditions":"Alzheimer's Disease","enrollment":92},{"nctId":"NCT04205578","phase":"PHASE3","title":"NBP in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular Events","status":"UNKNOWN","sponsor":"yuanli Zhao","startDate":"2020-01","conditions":"Moyamoya Disease, Ischemic Cerebral Infarction, Ischemic Stroke","enrollment":450},{"nctId":"NCT03906123","phase":"NA","title":"The Efficacy of DL-NBP in Patients With Mild Subcortical Ischemic Vascular Dementia","status":"UNKNOWN","sponsor":"Tianjin Medical University General Hospital","startDate":"2017-11-18","conditions":"Subcortical Vascular Dementia, Cerebral Small Vessel Diseases","enrollment":64},{"nctId":"NCT02993367","phase":"PHASE2, PHASE3","title":"The Efficacy of Butylphthalide Soft Capsules in Patents With VCIND","status":"UNKNOWN","sponsor":"The Second Hospital of Hebei Medical University","startDate":"2017-01","conditions":"Vascular Cognitive Impairment no Dementia","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"dl-3-n-butylphthalide (NBP)","genericName":"dl-3-n-butylphthalide (NBP)","companyName":"yuanli Zhao","companyId":"yuanli-zhao","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DL-3-n-butylphthalide (NBP) is a small molecule that acts as a vasodilator and neuroprotective agent. Used for Ischemic stroke, Cerebral ischemia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}