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Diosmin / Hesperidin
Diosmin and hesperidin are bioflavonoids that strengthen blood vessel walls and improve microcirculation by reducing capillary fragility and enhancing venous tone.
Diosmin and hesperidin are bioflavonoids that strengthen blood vessel walls and improve microcirculation by reducing capillary fragility and enhancing venous tone. Used for Chronic venous insufficiency, Hemorrhoids, Lymphedema.
At a glance
| Generic name | Diosmin / Hesperidin |
|---|---|
| Also known as | Venoactive drug, daflon |
| Sponsor | Pirogov Russian National Research Medical University |
| Drug class | Bioflavonoid / Venoactive agent |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular / Vascular disorders |
| Phase | FDA-approved |
Mechanism of action
These naturally occurring flavonoids work by increasing the resistance and elasticity of blood vessel walls, particularly in the venous system. They reduce inflammatory mediators and improve lymphatic drainage, thereby decreasing edema and improving blood flow in compromised vascular beds. The combination is thought to enhance the structural integrity of the endothelium and reduce vascular permeability.
Approved indications
- Chronic venous insufficiency
- Hemorrhoids
- Lymphedema
- Varicose veins
Common side effects
- Gastrointestinal disturbance
- Headache
- Dizziness
Key clinical trials
- Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous Insuficiency (PHASE4)
- Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers (NA)
- Silymarin vs Hesperidin/Diosmin in Fibromyalgia (NA)
- Effects of a Dietary Supplement Composed of Diosmin, Hesperidin, Bromelain, and Ruscus Aculeatus on the Quality of Life in Subjects With Lower Limb Disorders Possibly Prodromal to Chronic Venous Disease (NA)
- Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins (NA)
- Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty
- Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery (PHASE4)
- Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Diosmin / Hesperidin CI brief — competitive landscape report
- Diosmin / Hesperidin updates RSS · CI watch RSS
- Pirogov Russian National Research Medical University portfolio CI