{"id":"diosmin-hesperidin","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":{"setId":"24245e80-529f-0542-e063-6394a90a1fb4","title":"BRUSELIX BRUISING (VITAMIN C, ZINC, ARNICA MONTANA EXTRACT, BROMELAIN, DIOSMIN, RUTIN, CITRUS BIOFLAVONOIDS, HESPERIDIN METHYL CHALCONE) TABLET [PURETEK CORPORATION]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"These naturally occurring flavonoids work by increasing the resistance and elasticity of blood vessel walls, particularly in the venous system. They reduce inflammatory mediators and improve lymphatic drainage, thereby decreasing edema and improving blood flow in compromised vascular beds. The combination is thought to enhance the structural integrity of the endothelium and reduce vascular permeability.","oneSentence":"Diosmin and hesperidin are bioflavonoids that strengthen blood vessel walls and improve microcirculation by reducing capillary fragility and enhancing venous tone.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:35:27.054Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic venous insufficiency"},{"name":"Hemorrhoids"},{"name":"Lymphedema"},{"name":"Varicose veins"}]},"trialDetails":[{"nctId":"NCT06579482","phase":"PHASE4","title":"Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous Insuficiency","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2024-11-06","conditions":"Chronic Venous Insufficiency","enrollment":120},{"nctId":"NCT07300735","phase":"NA","title":"Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers","status":"RECRUITING","sponsor":"Alexandria University","startDate":"2025-03-01","conditions":"Hematologic Malignancy, Neutropenia, Bone Pain","enrollment":88},{"nctId":"NCT07293767","phase":"NA","title":"Silymarin vs Hesperidin/Diosmin in Fibromyalgia","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-11-16","conditions":"Fibromyalgia (FM)","enrollment":90},{"nctId":"NCT07185386","phase":"NA","title":"Effects of a Dietary Supplement Composed of Diosmin, Hesperidin, Bromelain, and Ruscus Aculeatus on the Quality of Life in Subjects With Lower Limb Disorders Possibly Prodromal to Chronic Venous Disease","status":"RECRUITING","sponsor":"Ekalab S.r.l.","startDate":"2025-05-28","conditions":"Prodromal to Chronic Venous Disease","enrollment":84},{"nctId":"NCT06367166","phase":"NA","title":"Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ryazan State Medical University","startDate":"2023-04-01","conditions":"Varicose Veins of Lower Limb, Varix, Vascular Diseases","enrollment":100},{"nctId":"NCT06753448","phase":"","title":"Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Ankara Etlik City Hospital","startDate":"2024-10-08","conditions":"Total Knee Arthroplasty, Venous Insufficiency of Leg","enrollment":190},{"nctId":"NCT06184438","phase":"PHASE4","title":"Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery","status":"COMPLETED","sponsor":"Taipei Medical University Shuang Ho Hospital","startDate":"2023-12-13","conditions":"Anal Fistula","enrollment":106},{"nctId":"NCT05756179","phase":"PHASE3","title":"Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis","status":"RECRUITING","sponsor":"Alexandria University","startDate":"2023-07-18","conditions":"Rheumatoid Arthritis","enrollment":80},{"nctId":"NCT06352099","phase":"NA","title":"Dietary Supplementation and Cognitive Functions in the Elderly","status":"COMPLETED","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2024-05-02","conditions":"Cognitive Impairment, Old Age; Debility","enrollment":36},{"nctId":"NCT06811220","phase":"PHASE3","title":"The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients","status":"NOT_YET_RECRUITING","sponsor":"Alexandria University","startDate":"2025-01-27","conditions":"Breast Cancer","enrollment":140},{"nctId":"NCT06584799","phase":"PHASE3","title":"Venoactive Drug Treatment of Pelvic Venous Disorders","status":"RECRUITING","sponsor":"Pirogov Russian National Research Medical University","startDate":"2024-12","conditions":"Pelvic Venous 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Lymphedema","enrollment":120},{"nctId":"NCT04933591","phase":"NA","title":"Impact of Treatment With VENARUS® on the Level of Monocyte Chemoattractant Protein 1 in Varicose Veins Blood","status":"COMPLETED","sponsor":"Pirogov Russian National Research Medical University","startDate":"2020-09-01","conditions":"Varicose Veins","enrollment":30},{"nctId":"NCT04290351","phase":"","title":"The Effect of Rubber Band Ligation in Bleeding Internal Hemorrhoids.","status":"COMPLETED","sponsor":"Konya Meram State Hospital","startDate":"2020-11-01","conditions":"Hemorrhoids, Internal","enrollment":69},{"nctId":"NCT05243706","phase":"PHASE3","title":"Evaluation of The Effect of Loratadine Versus Diosmin/Hesperidin Combination on Vinca Alkaloids Induced Neuropathy","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2022-03-01","conditions":"Vinca Alkaloid Adverse Reaction","enrollment":90},{"nctId":"NCT05243238","phase":"NA","title":"Hesperidin and Diosmin Effect on Metabolic Syndrome","status":"COMPLETED","sponsor":"Beni-Suef University","startDate":"2020-03-01","conditions":"Metabolic Syndrome and Diabetic Neuropathy","enrollment":129},{"nctId":"NCT05158192","phase":"PHASE1","title":"Bioavailability of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to Reference Product","status":"COMPLETED","sponsor":"Laboratorios Andromaco S.A.","startDate":"2021-11-04","conditions":"Bioequivalence","enrollment":12},{"nctId":"NCT05113420","phase":"","title":"The Efficacy and Safety of Different Phlebotonic Drugs in Children With Venous Malformations","status":"UNKNOWN","sponsor":"Center for Vascular Pathology, Moscow","startDate":"2019-09-17","conditions":"Drug Effect, Children, Only, Vascular Malformations","enrollment":1000},{"nctId":"NCT04452799","phase":"EARLY_PHASE1","title":"Hesperidin and Diosmin for Treatment of COVID-19","status":"UNKNOWN","sponsor":"Tanta University","startDate":"2020-07-01","conditions":"Coronavirus Infection","enrollment":100},{"nctId":"NCT04358497","phase":"PHASE4","title":"Endovascular Versus Medical Treatment for the Pelvic Congestion Syndrome","status":"UNKNOWN","sponsor":"Hospital de Clínicas Dr. Manuel Quintela","startDate":"2020-10-01","conditions":"Pelvic Congestive Syndrome, Pelvic Varices, Venous Disease","enrollment":120},{"nctId":"NCT03471910","phase":"PHASE4","title":"Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2017-06-20","conditions":"Venous Insufficiency","enrollment":120},{"nctId":"NCT02927483","phase":"PHASE3","title":"Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency","status":"UNKNOWN","sponsor":"SunWave Pharma","startDate":"2016-11","conditions":"Chronic Venous Insufficiency","enrollment":120},{"nctId":"NCT01477281","phase":"PHASE3","title":"Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon","status":"UNKNOWN","sponsor":"Laboratório Teuto Brasileiro S/A","startDate":"2012-02","conditions":"Chronic Venous Insufficiency, Disease","enrollment":82},{"nctId":"NCT01110512","phase":"PHASE3","title":"Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI)","status":"UNKNOWN","sponsor":"Azidus Brasil","startDate":"2010-10","conditions":"Venous Insufficiency","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Venoactive drug","daflon"],"phase":"marketed","status":"active","brandName":"Diosmin / Hesperidin","genericName":"Diosmin / Hesperidin","companyName":"Pirogov Russian National Research Medical University","companyId":"pirogov-russian-national-research-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diosmin and hesperidin are bioflavonoids that strengthen blood vessel walls and improve microcirculation by reducing capillary fragility and enhancing venous tone. Used for Chronic venous insufficiency, Hemorrhoids, Lymphedema.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}