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Diosmin and Hesperidin Combination
Diosmin and hesperidin are bioflavonoids that improve venous tone and reduce capillary permeability to enhance microcirculation and lymphatic drainage.
Diosmin and hesperidin are bioflavonoids that improve venous tone and reduce capillary permeability to enhance microcirculation and lymphatic drainage. Used for Chronic venous insufficiency, Hemorrhoids, Lymphedema.
At a glance
| Generic name | Diosmin and Hesperidin Combination |
|---|---|
| Also known as | Diosmin Plus 500 mg tablet |
| Sponsor | Ankara Etlik City Hospital |
| Drug class | Bioflavonoid combination |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
These naturally occurring flavonoids work synergistically to strengthen blood vessel walls, reduce inflammation, and improve blood flow in the venous and lymphatic systems. They are thought to increase the contractility of vascular smooth muscle and decrease endothelial permeability, thereby reducing edema and improving symptoms associated with chronic venous insufficiency and related conditions.
Approved indications
- Chronic venous insufficiency
- Hemorrhoids
- Lymphedema
- Venous leg ulcers
Common side effects
- Gastrointestinal disturbance
- Headache
- Dizziness
Key clinical trials
- Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous Insuficiency (PHASE4)
- Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers (NA)
- Effects of a Dietary Supplement Composed of Diosmin, Hesperidin, Bromelain, and Ruscus Aculeatus on the Quality of Life in Subjects With Lower Limb Disorders Possibly Prodromal to Chronic Venous Disease (NA)
- Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins (NA)
- Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty
- Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis (PHASE3)
- The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients (PHASE3)
- Venoactive Drug Treatment of Pelvic Venous Disorders (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Diosmin and Hesperidin Combination CI brief — competitive landscape report
- Diosmin and Hesperidin Combination updates RSS · CI watch RSS
- Ankara Etlik City Hospital portfolio CI