{"id":"diosmin-and-hesperidin-combination","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"These naturally occurring flavonoids work synergistically to strengthen blood vessel walls, reduce inflammation, and improve blood flow in the venous and lymphatic systems. They are thought to increase the contractility of vascular smooth muscle and decrease endothelial permeability, thereby reducing edema and improving symptoms associated with chronic venous insufficiency and related conditions.","oneSentence":"Diosmin and hesperidin are bioflavonoids that improve venous tone and reduce capillary permeability to enhance microcirculation and lymphatic drainage.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:37.098Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic venous insufficiency"},{"name":"Hemorrhoids"},{"name":"Lymphedema"},{"name":"Venous leg ulcers"}]},"trialDetails":[{"nctId":"NCT06579482","phase":"PHASE4","title":"Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous Insuficiency","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2024-11-06","conditions":"Chronic Venous Insufficiency","enrollment":120},{"nctId":"NCT07300735","phase":"NA","title":"Comparing Diosmin-Hesperidin and Loratadine to Prevent Bone Pain From G-CSF in Patients With Blood Cancers","status":"RECRUITING","sponsor":"Alexandria University","startDate":"2025-03-01","conditions":"Hematologic Malignancy, Neutropenia, Bone Pain","enrollment":88},{"nctId":"NCT07185386","phase":"NA","title":"Effects of a Dietary Supplement Composed of Diosmin, Hesperidin, Bromelain, and Ruscus Aculeatus on the Quality of Life in Subjects With Lower Limb Disorders Possibly Prodromal to Chronic Venous Disease","status":"RECRUITING","sponsor":"Ekalab S.r.l.","startDate":"2025-05-28","conditions":"Prodromal to Chronic Venous Disease","enrollment":84},{"nctId":"NCT06367166","phase":"NA","title":"Effects of Bioflavanoids on Vascular Wall Remodeling in Patients With Varicose Veins","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ryazan State Medical University","startDate":"2023-04-01","conditions":"Varicose Veins of Lower Limb, Varix, Vascular Diseases","enrollment":100},{"nctId":"NCT06753448","phase":"","title":"Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Ankara Etlik City Hospital","startDate":"2024-10-08","conditions":"Total Knee Arthroplasty, Venous Insufficiency of Leg","enrollment":190},{"nctId":"NCT05756179","phase":"PHASE3","title":"Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis","status":"RECRUITING","sponsor":"Alexandria University","startDate":"2023-07-18","conditions":"Rheumatoid Arthritis","enrollment":80},{"nctId":"NCT06811220","phase":"PHASE3","title":"The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients","status":"NOT_YET_RECRUITING","sponsor":"Alexandria University","startDate":"2025-01-27","conditions":"Breast Cancer","enrollment":140},{"nctId":"NCT06584799","phase":"PHASE3","title":"Venoactive Drug Treatment of Pelvic Venous Disorders","status":"RECRUITING","sponsor":"Pirogov Russian National Research Medical University","startDate":"2024-12","conditions":"Pelvic Venous Disorders","enrollment":150},{"nctId":"NCT06546111","phase":"PHASE1, PHASE2","title":"Clinical Study to Evaluate the Possible Efficacy and Safety of Diosmin and Hesperidin Combined Therapy in Patients With Helicobacter Pylori Infection","status":"RECRUITING","sponsor":"Sadat City University","startDate":"2024-10-01","conditions":"Helicobacter Pylori Infection","enrollment":46},{"nctId":"NCT06083935","phase":"PHASE4","title":"Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2023-11-01","conditions":"Poly Cystic Ovary Syndrome","enrollment":120},{"nctId":"NCT05243706","phase":"PHASE3","title":"Evaluation of The Effect of Loratadine Versus Diosmin/Hesperidin Combination on Vinca Alkaloids Induced Neuropathy","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2022-03-01","conditions":"Vinca Alkaloid Adverse Reaction","enrollment":90},{"nctId":"NCT05243238","phase":"NA","title":"Hesperidin and Diosmin Effect on Metabolic Syndrome","status":"COMPLETED","sponsor":"Beni-Suef University","startDate":"2020-03-01","conditions":"Metabolic Syndrome and Diabetic Neuropathy","enrollment":129},{"nctId":"NCT02927483","phase":"PHASE3","title":"Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency","status":"UNKNOWN","sponsor":"SunWave Pharma","startDate":"2016-11","conditions":"Chronic Venous Insufficiency","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Diosmin Plus 500 mg tablet"],"phase":"phase_3","status":"active","brandName":"Diosmin and Hesperidin Combination","genericName":"Diosmin and Hesperidin Combination","companyName":"Ankara Etlik City Hospital","companyId":"ankara-etlik-city-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diosmin and hesperidin are bioflavonoids that improve venous tone and reduce capillary permeability to enhance microcirculation and lymphatic drainage. Used for Chronic venous insufficiency, Hemorrhoids, Lymphedema.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}