Last reviewed 2026-04-23 · How we verify

Diosmin 600

Diosmin is a bioflavonoid that improves venous tone and reduces capillary fragility by strengthening blood vessel walls and reducing inflammation.

Diosmin is a bioflavonoid that improves venous tone and reduces capillary fragility by strengthening blood vessel walls and reducing inflammation. Used for Chronic venous insufficiency, Hemorrhoids, Lymphedema.

At a glance

Mechanism of action

Diosmin is a naturally occurring flavonoid derivative that acts as a venoactive agent, enhancing venous return and lymphatic drainage while reducing vascular permeability. It works by increasing the tone and contractility of venous smooth muscle and decreasing inflammatory mediators, thereby improving microcirculation and reducing symptoms associated with chronic venous insufficiency.

Approved indications

• Chronic venous insufficiency
• Hemorrhoids
• Lymphedema

Common side effects

• Gastrointestinal disturbances
• Headache
• Dizziness

Key clinical trials

• Venoactive Drug Treatment of Pelvic Venous Disorders (PHASE3)
• the Efficacy and Safety of Diosmin on Non-diabetic Patients With Non-alcoholic Steatohepatitis. (PHASE3)
• the Efficacy and Safety of Diosmin in Patients With Ulcerative Colitis (PHASE3)
• Rivaroxaban With Diosmin in Long-term Treatment of Deep Vein Thrombosis (PHASE4)
• Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency (PHASE4)

Primary sources

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