{"id":"diosmin-600","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diosmin is a naturally occurring flavonoid derivative that acts as a venoactive agent, enhancing venous return and lymphatic drainage while reducing vascular permeability. It works by increasing the tone and contractility of venous smooth muscle and decreasing inflammatory mediators, thereby improving microcirculation and reducing symptoms associated with chronic venous insufficiency.","oneSentence":"Diosmin is a bioflavonoid that improves venous tone and reduces capillary fragility by strengthening blood vessel walls and reducing inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:45:56.126Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic venous insufficiency"},{"name":"Hemorrhoids"},{"name":"Lymphedema"}]},"trialDetails":[{"nctId":"NCT06584799","phase":"PHASE3","title":"Venoactive Drug Treatment of Pelvic Venous Disorders","status":"RECRUITING","sponsor":"Pirogov Russian National Research Medical University","startDate":"2024-12","conditions":"Pelvic Venous Disorders","enrollment":150},{"nctId":"NCT05942547","phase":"PHASE3","title":"the Efficacy and Safety of Diosmin on Non-diabetic Patients With Non-alcoholic Steatohepatitis.","status":"UNKNOWN","sponsor":"Tanta University","startDate":"2023-07-10","conditions":"Non Alcoholic Steatohepatitis","enrollment":48},{"nctId":"NCT05626166","phase":"PHASE3","title":"the Efficacy and Safety of Diosmin in Patients With Ulcerative Colitis","status":"UNKNOWN","sponsor":"Tanta University","startDate":"2022-12-15","conditions":"Ulcerative Colitis","enrollment":60},{"nctId":"NCT03413618","phase":"PHASE4","title":"Rivaroxaban With Diosmin in Long-term Treatment of Deep Vein Thrombosis","status":"COMPLETED","sponsor":"Pirogov Russian National Research Medical University","startDate":"2017-12-20","conditions":"Deep Vein Thrombosis, Postthrombotic Syndrome","enrollment":90},{"nctId":"NCT03471910","phase":"PHASE4","title":"Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2017-06-20","conditions":"Venous Insufficiency","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Diosmin 600","genericName":"Diosmin 600","companyName":"Pirogov Russian National Research Medical University","companyId":"pirogov-russian-national-research-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diosmin is a bioflavonoid that improves venous tone and reduces capillary fragility by strengthening blood vessel walls and reducing inflammation. Used for Chronic venous insufficiency, Hemorrhoids, Lymphedema.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}