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Dinoprostone vaginal pessary
Dinoprostone is a prostaglandin F2α analog that binds to prostaglandin receptors on the uterus to stimulate myometrial contractions and promote cervical ripening and labor induction.
Dinoprostone is a prostaglandin F2α analog that binds to prostaglandin receptors on the uterus to stimulate myometrial contractions and promote cervical ripening and labor induction. Used for Cervical ripening and labor induction in pregnant women at or near term, Management of incomplete abortion or miscarriage.
At a glance
| Generic name | Dinoprostone vaginal pessary |
|---|---|
| Also known as | Propess, Ferring, Milan, Italy |
| Sponsor | Università degli Studi di Brescia |
| Drug class | Prostaglandin F2α analog |
| Target | Prostaglandin F (FP) receptor |
| Modality | Small molecule |
| Therapeutic area | Obstetrics |
| Phase | FDA-approved |
Mechanism of action
Dinoprostone acts as a direct agonist of prostaglandin F (FP) receptors on uterine smooth muscle, triggering rhythmic contractions similar to those occurring during spontaneous labor. When administered as a vaginal pessary, it also promotes cervical softening and dilation by increasing local prostaglandin concentrations, facilitating cervical ripening in preparation for labor or delivery.
Approved indications
- Cervical ripening and labor induction in pregnant women at or near term
- Management of incomplete abortion or miscarriage
Common side effects
- Uterine hyperstimulation
- Vaginal irritation or discomfort
- Fever
- Nausea and vomiting
- Diarrhea
- Abdominal pain or cramping
Key clinical trials
- Mechanical Dilation of the Cervix in a Scarred Uterus (NA)
- Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter (PHASE4)
- Gemeprost Versus Dinoprostone in First Trimester Miscarriages (PHASE2)
- Comparison Between Propess and Cook Double-balloon Catheter for Cervical Priming (PHASE4)
- Foley Catheter Versus PGE2 for Labor Induction at Term: a Pilot Study (PHASE4)
- What After the First Propess (PHASE2)
- Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term (NA)
- Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Nulliparas at Term (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dinoprostone vaginal pessary CI brief — competitive landscape report
- Dinoprostone vaginal pessary updates RSS · CI watch RSS
- Università degli Studi di Brescia portfolio CI