{"id":"dinoprostone-vaginal-pessary","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Vaginal irritation or discomfort"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain or cramping"}]},"_chembl":{"chemblId":"CHEMBL548","moleculeType":"Small molecule","molecularWeight":"352.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dinoprostone acts as a direct agonist of prostaglandin F (FP) receptors on uterine smooth muscle, triggering rhythmic contractions similar to those occurring during spontaneous labor. When administered as a vaginal pessary, it also promotes cervical softening and dilation by increasing local prostaglandin concentrations, facilitating cervical ripening in preparation for labor or delivery.","oneSentence":"Dinoprostone is a prostaglandin F2α analog that binds to prostaglandin receptors on the uterus to stimulate myometrial contractions and promote cervical ripening and labor induction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:41.612Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical ripening and labor induction in pregnant women at or near term"},{"name":"Management of incomplete abortion or miscarriage"}]},"trialDetails":[{"nctId":"NCT03471858","phase":"NA","title":"Mechanical Dilation of the Cervix in a Scarred Uterus","status":"COMPLETED","sponsor":"Ministry of Health, Singapore","startDate":"2019-08-29","conditions":"Pregnancy Related, Labor Complication, Cesarean Section; Dehiscence","enrollment":44},{"nctId":"NCT06803992","phase":"PHASE4","title":"Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter","status":"RECRUITING","sponsor":"HaEmek Medical Center, Israel","startDate":"2025-04-06","conditions":"Induction of Labor","enrollment":140},{"nctId":"NCT05342467","phase":"PHASE2","title":"Gemeprost Versus Dinoprostone in First Trimester Miscarriages","status":"COMPLETED","sponsor":"National University of Malaysia","startDate":"2022-11-11","conditions":"Missed Abortion, Medical; Abortion, Fetus, Incomplete Abortion","enrollment":101},{"nctId":"NCT06438081","phase":"PHASE4","title":"Comparison Between Propess and Cook Double-balloon Catheter for Cervical Priming","status":"RECRUITING","sponsor":"The University of Hong Kong","startDate":"2024-06-01","conditions":"Delivery Problem","enrollment":28},{"nctId":"NCT04780269","phase":"PHASE4","title":"Foley Catheter Versus PGE2 for Labor Induction at Term: a Pilot Study","status":"SUSPENDED","sponsor":"Guangzhou Women and Children's Medical Center","startDate":"2023-12","conditions":"Labor Induction, Induced Delivery","enrollment":200},{"nctId":"NCT02956785","phase":"PHASE2","title":"What After the First Propess","status":"TERMINATED","sponsor":"South Warwickshire NHS Foundation Trust","startDate":"2017-01","conditions":"Induction of Labor","enrollment":85},{"nctId":"NCT02618096","phase":"NA","title":"Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2015-10","conditions":"Failed Induction of Labor","enrollment":154},{"nctId":"NCT02416583","phase":"NA","title":"Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Nulliparas at Term","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2015-04","conditions":"Failed Induction of Labor","enrollment":140},{"nctId":"NCT03199820","phase":"PHASE4","title":"Balloon Catheter Versus Propess for Labour Induction","status":"UNKNOWN","sponsor":"St George's, University of London","startDate":"2017-09-22","conditions":"Childbirth Problems, Labor Complication","enrollment":120},{"nctId":"NCT03625518","phase":"EARLY_PHASE1","title":"Mode of Induction in Fetal Growth Restriction and Its Affects on Fetal and Maternal Outcomes","status":"UNKNOWN","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2018-09","conditions":"Fetal Growth Retardation, Induction of Labor Affected Fetus / Newborn","enrollment":280},{"nctId":"NCT01765881","phase":"PHASE2","title":"Comparison Between 25 µg Vaginal Misoprostol vs Slow Release Pessary PGE2","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2012-09","conditions":"Delivery Uterine","enrollment":1700},{"nctId":"NCT02393144","phase":"NA","title":"Analysis of Contemporary Labor Patterns Measured Via Transperineal Ultrasonography","status":"UNKNOWN","sponsor":"Ankara University","startDate":"2015-02","conditions":"Pregnancy, Obstetric Labor","enrollment":1000},{"nctId":"NCT01635439","phase":"PHASE3","title":"Prostin and Propess in Induction of Labor","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2010-12","conditions":"Labor Pain","enrollment":200},{"nctId":"NCT01860521","phase":"NA","title":"Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Termination of Pregnancy Analgesia","status":"COMPLETED","sponsor":"IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","startDate":"2011-09","conditions":"Medical; Abortion, Fetus","enrollment":104},{"nctId":"NCT01190163","phase":"PHASE4","title":"Open Label Comparative Trial of Dinoprostone Plus or Minus Oxytocin Versus Oxytocin Alone in Cervical Ripening for Labor Induction","status":"TERMINATED","sponsor":"Ferring Pharmaceuticals","startDate":"2010-06","conditions":"Vaginal Delivery, Cesarean Section","enrollment":170},{"nctId":"NCT01099280","phase":"PHASE3","title":"Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin","status":"COMPLETED","sponsor":"Erzincan Military Hospital","startDate":"2009-11","conditions":"Labor, Induction, PROM (Pregnancy)","enrollment":225},{"nctId":"NCT00843362","phase":"PHASE4","title":"24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction","status":"COMPLETED","sponsor":"Università degli Studi di Brescia","startDate":"2006-12","conditions":"Labor, Induced, Cervical Ripening","enrollment":133},{"nctId":"NCT00299754","phase":"PHASE3","title":"Trial Of Misoprostol And Dinoprostone Vaginal Pessaries for Cervical Priming (TROMAD Study)","status":"COMPLETED","sponsor":"KK Women's and Children's Hospital","startDate":"2003-01","conditions":"Induction of Labour","enrollment":171}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Propess, Ferring, Milan, Italy"],"phase":"marketed","status":"active","brandName":"Dinoprostone vaginal pessary","genericName":"Dinoprostone vaginal pessary","companyName":"Università degli Studi di Brescia","companyId":"universit-degli-studi-di-brescia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dinoprostone is a prostaglandin F2α analog that binds to prostaglandin receptors on the uterus to stimulate myometrial contractions and promote cervical ripening and labor induction. Used for Cervical ripening and labor induction in pregnant women at or near term, Management of incomplete abortion or miscarriage.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}