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DHEA replacement
DHEA replacement restores circulating dehydroepiandrosterone levels, a steroid hormone precursor that declines with age and may support immune function, bone health, and metabolic processes.
DHEA replacement restores circulating dehydroepiandrosterone levels, a steroid hormone precursor that declines with age and may support immune function, bone health, and metabolic processes. Used for Age-related decline in DHEA levels and associated functional impairment in older adults, Potential improvement in bone mineral density and fracture risk in aging populations.
At a glance
| Generic name | DHEA replacement |
|---|---|
| Sponsor | National Institute on Aging (NIA) |
| Drug class | Steroid hormone replacement |
| Target | DHEA receptor (putative); also serves as precursor to androgen and estrogen receptors |
| Modality | Small molecule |
| Therapeutic area | Geriatrics / Aging |
| Phase | Phase 3 |
Mechanism of action
DHEA is an endogenous steroid hormone produced by the adrenal glands that naturally declines with aging. Supplementation aims to restore youthful hormone levels and may enhance immune response, improve bone mineral density, support muscle mass, and improve metabolic and cognitive function. The mechanism involves both direct receptor activation and conversion to downstream androgens and estrogens.
Approved indications
- Age-related decline in DHEA levels and associated functional impairment in older adults
- Potential improvement in bone mineral density and fracture risk in aging populations
Common side effects
- Acne
- Hirsutism or androgenic effects
- Mood changes
- Headache
- Insomnia
Key clinical trials
- Vaginal Ecosystem and Network in the United States Study
- Assess the Effect of Dehydroepiandrosterone (DHEA) or Other Androgenic Agents Over Markers of Ovarian Reserve (PHASE1)
- Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa (PHASE2, PHASE3)
- Electroacupuncture for Diminished Ovarian Reserve (PHASE1)
- DHEA Replacement in Adrenalectomized/Hypoadrenal Patients (NA)
- DHEA and Testosterone Replacement in Elderly (NA)
- Effects of Dehydroepiandrosterone (DHEA) in Humans (PHASE3)
- Survey in Patients With Chronic Adrenal Insufficiency in Germany
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |