{"id":"dhea-replacement","safety":{"commonSideEffects":[{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Hirsutism or androgenic effects"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Insomnia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DHEA is an endogenous steroid hormone produced by the adrenal glands that naturally declines with aging. Supplementation aims to restore youthful hormone levels and may enhance immune response, improve bone mineral density, support muscle mass, and improve metabolic and cognitive function. The mechanism involves both direct receptor activation and conversion to downstream androgens and estrogens.","oneSentence":"DHEA replacement restores circulating dehydroepiandrosterone levels, a steroid hormone precursor that declines with age and may support immune function, bone health, and metabolic processes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:25.114Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Age-related decline in DHEA levels and associated functional impairment in older adults"},{"name":"Potential improvement in bone mineral density and fracture risk in aging populations"}]},"trialDetails":[{"nctId":"NCT06472765","phase":"","title":"Vaginal Ecosystem and Network in the United States Study","status":"ENROLLING_BY_INVITATION","sponsor":"Vaginal Biome Science","startDate":"2024-05-16","conditions":"Bacterial Vaginosis, Candidiasis, Urinary Tract Infections","enrollment":3250},{"nctId":"NCT02268032","phase":"PHASE1","title":"Assess the Effect of Dehydroepiandrosterone (DHEA) or Other Androgenic Agents Over Markers of Ovarian Reserve","status":"COMPLETED","sponsor":"Laboratorios Andromaco S.A.","startDate":"2014-07-15","conditions":"Healthy Women, Infertility, Female","enrollment":94},{"nctId":"NCT00310791","phase":"PHASE2, PHASE3","title":"Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa","status":"COMPLETED","sponsor":"Boston Children's Hospital","startDate":"2004-04","conditions":"Anorexia Nervosa","enrollment":80},{"nctId":"NCT02229604","phase":"PHASE1","title":"Electroacupuncture for Diminished Ovarian Reserve","status":"COMPLETED","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2014-01","conditions":"Irregular Menses","enrollment":57},{"nctId":"NCT00279929","phase":"NA","title":"DHEA Replacement in Adrenalectomized/Hypoadrenal Patients","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2002-07","conditions":"Aging, Dehydroepiandosterone Replacement, DHEA Replacement","enrollment":32},{"nctId":"NCT00254371","phase":"NA","title":"DHEA and Testosterone Replacement in Elderly","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"1998-07","conditions":"Aging, Low DHEA for Women, Low Testosterone and DHEA for Men","enrollment":150},{"nctId":"NCT00182975","phase":"PHASE3","title":"Effects of Dehydroepiandrosterone (DHEA) in Humans","status":"COMPLETED","sponsor":"National Institute on Aging (NIA)","startDate":"2002-09","conditions":"Aging","enrollment":142},{"nctId":"NCT00444119","phase":"","title":"Survey in Patients With Chronic Adrenal Insufficiency in Germany","status":"COMPLETED","sponsor":"University of Wuerzburg","startDate":"2004-05","conditions":"Adrenal Insufficiency, Addison's Disease","enrollment":""},{"nctId":"NCT00004313","phase":"PHASE3","title":"Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency","status":"COMPLETED","sponsor":"National Center for Research Resources (NCRR)","startDate":"1995-08","conditions":"Addison's Disease","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":95,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"DHEA replacement","genericName":"DHEA replacement","companyName":"National Institute on Aging (NIA)","companyId":"national-institute-on-aging-nia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DHEA replacement restores circulating dehydroepiandrosterone levels, a steroid hormone precursor that declines with age and may support immune function, bone health, and metabolic processes. Used for Age-related decline in DHEA levels and associated functional impairment in older adults, Potential improvement in bone mineral density and fracture risk in aging populations.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}