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DHEA (1.0%)
DHEA is a steroid hormone precursor that acts as a prohormone, being converted in peripheral tissues to testosterone and estrogen to restore hormonal balance.
DHEA is a steroid hormone precursor that acts as a prohormone, being converted in peripheral tissues to testosterone and estrogen to restore hormonal balance. Used for Moderate to severe dyspareunia (painful intercourse) due to menopause, Vaginal atrophy and related menopausal symptoms.
At a glance
| Generic name | DHEA (1.0%) |
|---|---|
| Also known as | Prasterone, Dehydroepiandrosterone |
| Sponsor | EndoCeutics Inc. |
| Drug class | Steroid hormone / Prohormone |
| Target | Androgen receptor, Estrogen receptor (via peripheral conversion) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Women's Health |
| Phase | Phase 3 |
Mechanism of action
DHEA (dehydroepiandrosterone) is an endogenous steroid hormone that declines with age. When administered, it serves as a substrate for enzymatic conversion to active sex hormones (testosterone and estrogen) in target tissues. This mechanism aims to restore age-related hormonal deficiencies and improve symptoms associated with menopause and aging.
Approved indications
- Moderate to severe dyspareunia (painful intercourse) due to menopause
- Vaginal atrophy and related menopausal symptoms
Common side effects
- Acne
- Hirsutism
- Vaginal discharge
- Headache
- Breast tenderness
Key clinical trials
- Studies of Sulfur Metabolism in Humans (EARLY_PHASE1)
- Topical DHEA Against Vaginal Atrophy (PHASE3)
- DHEA Bioavailability Following Administration of Vaginal Suppositories in Post-Menopausal Women With Vaginal Atrophy (PHASE1)
- Electroacupuncture for Diminished Ovarian Reserve (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |