{"id":"dhea-1-0","safety":{"commonSideEffects":[{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Hirsutism"},{"rate":null,"effect":"Vaginal discharge"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Breast tenderness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"DHEA (dehydroepiandrosterone) is an endogenous steroid hormone that declines with age. When administered, it serves as a substrate for enzymatic conversion to active sex hormones (testosterone and estrogen) in target tissues. This mechanism aims to restore age-related hormonal deficiencies and improve symptoms associated with menopause and aging.","oneSentence":"DHEA is a steroid hormone precursor that acts as a prohormone, being converted in peripheral tissues to testosterone and estrogen to restore hormonal balance.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:25.086Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe dyspareunia (painful intercourse) due to menopause"},{"name":"Vaginal atrophy and related menopausal symptoms"}]},"trialDetails":[{"nctId":"NCT03383133","phase":"EARLY_PHASE1","title":"Studies of Sulfur Metabolism in Humans","status":"COMPLETED","sponsor":"Albert Einstein College of Medicine","startDate":"2018-01-11","conditions":"Metabolic Side Effects of Drugs","enrollment":1},{"nctId":"NCT01846442","phase":"PHASE3","title":"Topical DHEA Against Vaginal Atrophy","status":"COMPLETED","sponsor":"EndoCeutics Inc.","startDate":"2007-06","conditions":"Vaginal Atrophy","enrollment":218},{"nctId":"NCT00429806","phase":"PHASE1","title":"DHEA Bioavailability Following Administration of Vaginal Suppositories in Post-Menopausal Women With Vaginal Atrophy","status":"COMPLETED","sponsor":"CHU de Quebec-Universite Laval","startDate":"2006-11","conditions":"Vaginal Atrophy","enrollment":40},{"nctId":"NCT02229604","phase":"PHASE1","title":"Electroacupuncture for Diminished Ovarian Reserve","status":"COMPLETED","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2014-01","conditions":"Irregular Menses","enrollment":57}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":252,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Prasterone, Dehydroepiandrosterone"],"phase":"phase_3","status":"active","brandName":"DHEA (1.0%)","genericName":"DHEA (1.0%)","companyName":"EndoCeutics Inc.","companyId":"endoceutics-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DHEA is a steroid hormone precursor that acts as a prohormone, being converted in peripheral tissues to testosterone and estrogen to restore hormonal balance. Used for Moderate to severe dyspareunia (painful intercourse) due to menopause, Vaginal atrophy and related menopausal symptoms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}