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DHA-PQP coadministered with PQ
DHA-PQP (dihydroartemisinin-piperaquine) combined with primaquine works by killing malaria parasites at multiple lifecycle stages, with DHA-PQP targeting blood-stage parasites and primaquine targeting liver-stage and gametocyte forms.
DHA-PQP (dihydroartemisinin-piperaquine) combined with primaquine works by killing malaria parasites at multiple lifecycle stages, with DHA-PQP targeting blood-stage parasites and primaquine targeting liver-stage and gametocyte forms. Used for Malaria caused by Plasmodium vivax (including relapsing malaria), Malaria caused by Plasmodium ovale, Uncomplicated malaria in endemic regions.
At a glance
| Generic name | DHA-PQP coadministered with PQ |
|---|---|
| Also known as | Experimental treatment with potential synergy |
| Sponsor | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado |
| Drug class | Artemisinin-based combination therapy (ACT) with 8-aminoquinoline |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Dihydroartemisinin-piperaquine is a fixed-dose artemisinin-based combination therapy that rapidly eliminates asexual blood-stage Plasmodium parasites. Primaquine is added to target hypnozoites in the liver (preventing relapse in P. vivax and P. ovale) and to eliminate gametocytes (blocking transmission). This combination addresses both clinical cure and transmission reduction.
Approved indications
- Malaria caused by Plasmodium vivax (including relapsing malaria)
- Malaria caused by Plasmodium ovale
- Uncomplicated malaria in endemic regions
Common side effects
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Headache
- Hemolysis (in G6PD-deficient patients receiving primaquine)
- Pruritus
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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