{"id":"dha-pqp-coadministered-with-pq","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances (nausea, vomiting, diarrhea)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hemolysis (in G6PD-deficient patients receiving primaquine)"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dihydroartemisinin-piperaquine is a fixed-dose artemisinin-based combination therapy that rapidly eliminates asexual blood-stage Plasmodium parasites. Primaquine is added to target hypnozoites in the liver (preventing relapse in P. vivax and P. ovale) and to eliminate gametocytes (blocking transmission). This combination addresses both clinical cure and transmission reduction.","oneSentence":"DHA-PQP (dihydroartemisinin-piperaquine) combined with primaquine works by killing malaria parasites at multiple lifecycle stages, with DHA-PQP targeting blood-stage parasites and primaquine targeting liver-stage and gametocyte forms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:25.123Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria caused by Plasmodium vivax (including relapsing malaria)"},{"name":"Malaria caused by Plasmodium ovale"},{"name":"Uncomplicated malaria in endemic regions"}]},"trialDetails":[{"nctId":"NCT03208907","phase":"PHASE3","title":"DHA-PQP vs Chloroquine and Primaquine for Radical Cure of Vivax Malaria in Brazil","status":"COMPLETED","sponsor":"Fundação de Medicina Tropical Dr. Heitor Vieira Dourado","startDate":"2018-07-05","conditions":"Malaria, Vivax, Therapeutics","enrollment":419}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Experimental treatment with potential synergy"],"phase":"phase_3","status":"active","brandName":"DHA-PQP coadministered with PQ","genericName":"DHA-PQP coadministered with PQ","companyName":"Fundação de Medicina Tropical Dr. Heitor Vieira Dourado","companyId":"funda-o-de-medicina-tropical-dr-heitor-vieira-dourado","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DHA-PQP (dihydroartemisinin-piperaquine) combined with primaquine works by killing malaria parasites at multiple lifecycle stages, with DHA-PQP targeting blood-stage parasites and primaquine targeting liver-stage and gametocyte forms. Used for Malaria caused by Plasmodium vivax (including relapsing malaria), Malaria caused by Plasmodium ovale, Uncomplicated malaria in endemic regions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}