Last reviewed · How we verify
dextromethorophan; placebo; diphenhydramine/phenylephrine/cocoa
This is a combination product containing dextromethorphan (a cough suppressant), diphenhydramine (an antihistamine), phenylephrine (a decongestant), and cocoa, used to manage cold and cough symptoms.
This is a combination product containing dextromethorphan (a cough suppressant), diphenhydramine (an antihistamine), phenylephrine (a decongestant), and cocoa, used to manage cold and cough symptoms. Used for Symptomatic relief of cough, nasal congestion, sneezing, and itching associated with the common cold or upper respiratory infections.
At a glance
| Generic name | dextromethorophan; placebo; diphenhydramine/phenylephrine/cocoa |
|---|---|
| Sponsor | Montefiore Medical Center |
| Drug class | Combination cold and cough remedy |
| Modality | Small molecule |
| Therapeutic area | Respiratory / Cold and Cough |
| Phase | FDA-approved |
Mechanism of action
Dextromethorphan acts as a non-narcotic cough suppressant by depressing the cough center in the medulla. Diphenhydramine is a first-generation antihistamine that reduces histamine-mediated symptoms like sneezing and itching. Phenylephrine is an alpha-1 adrenergic agonist that causes nasal vasoconstriction to relieve congestion. Cocoa may provide soothing properties and flavor.
Approved indications
- Symptomatic relief of cough, nasal congestion, sneezing, and itching associated with the common cold or upper respiratory infections
Common side effects
- Drowsiness
- Dizziness
- Nausea
- Headache
- Nervousness or excitability
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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