{"id":"dextromethorophan-placebo-diphenhydramine-phenylephrine-cocoa","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nervousness or excitability"}]},"_chembl":{"chemblId":"CHEMBL1200339","moleculeType":"Small molecule","molecularWeight":"203.67"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dextromethorphan acts as a non-narcotic cough suppressant by depressing the cough center in the medulla. Diphenhydramine is a first-generation antihistamine that reduces histamine-mediated symptoms like sneezing and itching. Phenylephrine is an alpha-1 adrenergic agonist that causes nasal vasoconstriction to relieve congestion. Cocoa may provide soothing properties and flavor.","oneSentence":"This is a combination product containing dextromethorphan (a cough suppressant), diphenhydramine (an antihistamine), phenylephrine (a decongestant), and cocoa, used to manage cold and cough symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:44:33.354Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Symptomatic relief of cough, nasal congestion, sneezing, and itching associated with the common cold or upper respiratory infections"}]},"trialDetails":[{"nctId":"NCT02062710","phase":"PHASE4","title":"Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2014-01","conditions":"Cough Reflex Sensitivity","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"dextromethorophan; placebo; diphenhydramine/phenylephrine/cocoa","genericName":"dextromethorophan; placebo; diphenhydramine/phenylephrine/cocoa","companyName":"Montefiore Medical Center","companyId":"montefiore-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination product containing dextromethorphan (a cough suppressant), diphenhydramine (an antihistamine), phenylephrine (a decongestant), and cocoa, used to manage cold and cough symptoms. Used for Symptomatic relief of cough, nasal congestion, sneezing, and itching associated with the common cold or upper respiratory infections.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}