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Dexamethasone Mouth Rinse

Genentech, Inc. · Phase 3 active Small molecule

Dexamethasone Mouth Rinse is a Corticosteroid Small molecule drug developed by Genentech, Inc.. It is currently in Phase 3 development for Oral inflammation and ulceration (aphthous ulcers, oral mucositis), Post-operative oral pain and swelling.

Dexamethasone is a corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and reducing production of pro-inflammatory cytokines.

Dexamethasone is a corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and reducing production of pro-inflammatory cytokines. Used for Oral inflammation and ulceration (aphthous ulcers, oral mucositis), Post-operative oral pain and swelling.

At a glance

Generic nameDexamethasone Mouth Rinse
SponsorGenentech, Inc.
Drug classCorticosteroid
TargetGlucocorticoid receptor
ModalitySmall molecule
Therapeutic areaImmunology / Dermatology / Oral Medicine
PhasePhase 3

Mechanism of action

Dexamethasone exerts its anti-inflammatory effects by translocating to the nucleus and modulating gene expression of inflammatory mediators. When formulated as a mouth rinse, it delivers localized corticosteroid activity to oral tissues to reduce inflammation, pain, and swelling. This topical delivery minimizes systemic exposure while targeting the oral cavity directly.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Dexamethasone Mouth Rinse

What is Dexamethasone Mouth Rinse?

Dexamethasone Mouth Rinse is a Corticosteroid drug developed by Genentech, Inc., indicated for Oral inflammation and ulceration (aphthous ulcers, oral mucositis), Post-operative oral pain and swelling.

How does Dexamethasone Mouth Rinse work?

Dexamethasone is a corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and reducing production of pro-inflammatory cytokines.

What is Dexamethasone Mouth Rinse used for?

Dexamethasone Mouth Rinse is indicated for Oral inflammation and ulceration (aphthous ulcers, oral mucositis), Post-operative oral pain and swelling.

Who makes Dexamethasone Mouth Rinse?

Dexamethasone Mouth Rinse is developed by Genentech, Inc. (see full Genentech, Inc. pipeline at /company/genentech-inc).

What drug class is Dexamethasone Mouth Rinse in?

Dexamethasone Mouth Rinse belongs to the Corticosteroid class. See all Corticosteroid drugs at /class/corticosteroid.

What development phase is Dexamethasone Mouth Rinse in?

Dexamethasone Mouth Rinse is in Phase 3.

What are the side effects of Dexamethasone Mouth Rinse?

Common side effects of Dexamethasone Mouth Rinse include Oral candidiasis, Local irritation or burning, Taste disturbance.

What does Dexamethasone Mouth Rinse target?

Dexamethasone Mouth Rinse targets Glucocorticoid receptor and is a Corticosteroid.

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