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Dexamethasone and ondasetron
Dexamethasone suppresses inflammation and immune responses via glucocorticoid receptor activation, while ondansetron blocks serotonin 5-HT3 receptors to prevent nausea and vomiting.
Dexamethasone suppresses inflammation and immune responses via glucocorticoid receptor activation, while ondansetron blocks serotonin 5-HT3 receptors to prevent nausea and vomiting. Used for Prevention and management of nausea and vomiting in pediatric patients (likely postoperative or chemotherapy-related), Inflammatory conditions requiring corticosteroid support with antiemetic coverage.
At a glance
| Generic name | Dexamethasone and ondasetron |
|---|---|
| Also known as | Decadron and nausedron |
| Sponsor | Instituto Materno Infantil Prof. Fernando Figueira |
| Drug class | Corticosteroid + 5-HT3 antagonist combination |
| Target | Glucocorticoid receptor (dexamethasone); 5-HT3 receptor (ondansetron) |
| Modality | Small molecule |
| Therapeutic area | Supportive Care / Antiemetic |
| Phase | Phase 3 |
Mechanism of action
Dexamethasone is a potent corticosteroid that reduces inflammation, suppresses immune cell activity, and decreases cytokine production. Ondansetron is a selective 5-HT3 antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract, preventing chemotherapy-induced and postoperative nausea and vomiting. This combination is used to manage nausea, vomiting, and inflammatory complications in clinical settings.
Approved indications
- Prevention and management of nausea and vomiting in pediatric patients (likely postoperative or chemotherapy-related)
- Inflammatory conditions requiring corticosteroid support with antiemetic coverage
Common side effects
- Headache
- Constipation
- Hyperglycemia
- Insomnia
- Immunosuppression
Key clinical trials
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Dexamethasone Compared to Ondansetron and Dexamethasone for Prophylaxis of Postoperative Vomiting in Children (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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