{"id":"dexamethasone-and-ondasetron","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Immunosuppression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexamethasone is a potent corticosteroid that reduces inflammation, suppresses immune cell activity, and decreases cytokine production. Ondansetron is a selective 5-HT3 antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract, preventing chemotherapy-induced and postoperative nausea and vomiting. This combination is used to manage nausea, vomiting, and inflammatory complications in clinical settings.","oneSentence":"Dexamethasone suppresses inflammation and immune responses via glucocorticoid receptor activation, while ondansetron blocks serotonin 5-HT3 receptors to prevent nausea and vomiting.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:09:12.136Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and management of nausea and vomiting in pediatric patients (likely postoperative or chemotherapy-related)"},{"name":"Inflammatory conditions requiring corticosteroid support with antiemetic coverage"}]},"trialDetails":[{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT01297010","phase":"PHASE3","title":"Dexamethasone Compared to Ondansetron and Dexamethasone for Prophylaxis of Postoperative Vomiting in Children","status":"COMPLETED","sponsor":"Instituto Materno Infantil Prof. Fernando Figueira","startDate":"2011-03","conditions":"Vomiting Postoperative","enrollment":134}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Decadron and nausedron"],"phase":"phase_3","status":"active","brandName":"Dexamethasone and ondasetron","genericName":"Dexamethasone and ondasetron","companyName":"Instituto Materno Infantil Prof. Fernando Figueira","companyId":"instituto-materno-infantil-prof-fernando-figueira","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexamethasone suppresses inflammation and immune responses via glucocorticoid receptor activation, while ondansetron blocks serotonin 5-HT3 receptors to prevent nausea and vomiting. Used for Prevention and management of nausea and vomiting in pediatric patients (likely postoperative or chemotherapy-related), Inflammatory conditions requiring corticosteroid support with antiemetic coverage.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}