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Desflurane Inhalant Product
Desflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.
Desflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling. Used for General anesthesia for induction and maintenance during surgery, Anesthesia maintenance in adult and pediatric patients.
At a glance
| Generic name | Desflurane Inhalant Product |
|---|---|
| Also known as | Suprane |
| Sponsor | Sichuan Provincial People's Hospital |
| Drug class | Volatile inhalational anesthetic |
| Target | GABA receptors, NMDA receptors, potassium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Desflurane is a halogenated ether inhalational anesthetic that works primarily through potentiation of GABAergic inhibitory pathways and suppression of glutamatergic excitatory neurotransmission in the central nervous system. It produces rapid induction and emergence from anesthesia due to its low blood-gas solubility. The exact molecular mechanisms remain incompletely understood but involve modulation of multiple ion channels and neurotransmitter receptors.
Approved indications
- General anesthesia for induction and maintenance during surgery
- Anesthesia maintenance in adult and pediatric patients
Common side effects
- Emergence delirium
- Airway irritation
- Cough
- Increased salivation
- Hypotension
- Tachycardia
- Hepatotoxicity (rare)
Key clinical trials
- The Quality of Recovery From General Anesthesia With Desflurane for Fundus Surgery (EARLY_PHASE1)
- Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |