{"id":"desflurane-inhalant-product","safety":{"commonSideEffects":[{"rate":null,"effect":"Emergence delirium"},{"rate":null,"effect":"Airway irritation"},{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Increased salivation"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hepatotoxicity (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Desflurane is a halogenated ether inhalational anesthetic that works primarily through potentiation of GABAergic inhibitory pathways and suppression of glutamatergic excitatory neurotransmission in the central nervous system. It produces rapid induction and emergence from anesthesia due to its low blood-gas solubility. The exact molecular mechanisms remain incompletely understood but involve modulation of multiple ion channels and neurotransmitter receptors.","oneSentence":"Desflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:32:23.935Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General anesthesia for induction and maintenance during surgery"},{"name":"Anesthesia maintenance in adult and pediatric patients"}]},"trialDetails":[{"nctId":"NCT06241131","phase":"EARLY_PHASE1","title":"The Quality of Recovery From General Anesthesia With Desflurane for Fundus Surgery","status":"UNKNOWN","sponsor":"Sichuan Provincial People's Hospital","startDate":"2024-03-01","conditions":"Desflurane Anesthesia, Postoperative Recovery","enrollment":220},{"nctId":"NCT03417518","phase":"PHASE4","title":"Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Saint Pierre","startDate":"2015-01","conditions":"Anesthesia, Obesity","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":28,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Suprane"],"phase":"marketed","status":"active","brandName":"Desflurane Inhalant Product","genericName":"Desflurane Inhalant Product","companyName":"Sichuan Provincial People's Hospital","companyId":"sichuan-provincial-people-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling. Used for General anesthesia for induction and maintenance during surgery, Anesthesia maintenance in adult and pediatric patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}