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Del Nido
Del Nido cardioplegia is a cold crystalloid solution that rapidly cools and arrests the heart during cardiac surgery by delivering potassium and other electrolytes to stop myocardial contractions.
Del Nido cardioplegia is a cold crystalloid solution that rapidly cools and arrests the heart during cardiac surgery by delivering potassium and other electrolytes to stop myocardial contractions. Used for Myocardial protection during cardiac surgery requiring cardiopulmonary bypass.
At a glance
| Generic name | Del Nido |
|---|---|
| Sponsor | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau |
| Drug class | Cardioplegic solution |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Del Nido solution is a modified cardioplegic agent used during cardiopulmonary bypass to induce cardiac arrest and provide myocardial protection during open-heart surgery. It combines a single-dose potassium-based crystalloid formulation with additives including lidocaine, magnesium, and dextrose to reduce ischemic injury and improve post-operative cardiac function. The solution allows surgeons extended operative time (up to 3-4 hours) with a single administration, compared to traditional multi-dose cardioplegia protocols.
Approved indications
- Myocardial protection during cardiac surgery requiring cardiopulmonary bypass
Common side effects
- Hyperkalemia
- Myocardial dysfunction
- Arrhythmias post-operatively
Key clinical trials
- Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
- Effect of the Addition of Adenosine on Myocardial Protection During Cardiopulmonary Bypass (PHASE4)
- Impact of Different Cardioplegia Solutions on Indicators of Myocardial Injury During Coronary Surgery (NA)
- Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus HTK Solution Cardioplegia Solution in Cardiac Surgery (PHASE3)
- Effective Myocardial Protection Time of Del Nido Cardioplegia in Adult Cardiac Surgery
- Clinical Impact of Del Nido Cardioplegia in Adult Cardiac Surgery (PHASE4)
- Buckberg vs Del Nido in Isolated Aortic Valve Replacement (PHASE4)
- Clinical Outcomes Of Modified Del Nido Cardioplegia In Adult And Pediatric Cardiac Surgery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Del Nido CI brief — competitive landscape report
- Del Nido updates RSS · CI watch RSS
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau portfolio CI