{"id":"del-nido","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Myocardial dysfunction"},{"rate":null,"effect":"Arrhythmias post-operatively"}]},"_chembl":{"chemblId":"CHEMBL4287001","moleculeType":"Unknown","molecularWeight":"2276.70"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Del Nido solution is a modified cardioplegic agent used during cardiopulmonary bypass to induce cardiac arrest and provide myocardial protection during open-heart surgery. It combines a single-dose potassium-based crystalloid formulation with additives including lidocaine, magnesium, and dextrose to reduce ischemic injury and improve post-operative cardiac function. The solution allows surgeons extended operative time (up to 3-4 hours) with a single administration, compared to traditional multi-dose cardioplegia protocols.","oneSentence":"Del Nido cardioplegia is a cold crystalloid solution that rapidly cools and arrests the heart during cardiac surgery by delivering potassium and other electrolytes to stop myocardial contractions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:32:14.168Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Myocardial protection during cardiac surgery requiring cardiopulmonary bypass"}]},"trialDetails":[{"nctId":"NCT06287372","phase":"","title":"Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia","status":"COMPLETED","sponsor":"Damascus University","startDate":"2022-07-04","conditions":"Myocardial Injury, Cardiac Surgery, Myocardial Protection","enrollment":20},{"nctId":"NCT07426237","phase":"PHASE4","title":"Effect of the Addition of Adenosine on Myocardial Protection During Cardiopulmonary Bypass","status":"NOT_YET_RECRUITING","sponsor":"Hospital Nossa Senhora da Conceicao","startDate":"2026-03-30","conditions":"Myocardial Protection","enrollment":60},{"nctId":"NCT07358221","phase":"NA","title":"Impact of Different Cardioplegia Solutions on Indicators of Myocardial Injury During Coronary Surgery","status":"NOT_YET_RECRUITING","sponsor":"Damascus University","startDate":"2026-02","conditions":"Coronary Artery Bypass Grafting (CABG) Surgery, Myocardial Protection","enrollment":30},{"nctId":"NCT06414330","phase":"PHASE3","title":"Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus HTK Solution Cardioplegia Solution in Cardiac Surgery","status":"COMPLETED","sponsor":"Assiut University","startDate":"2024-06-01","conditions":"Cardiac Ischemia","enrollment":124},{"nctId":"NCT07249424","phase":"","title":"Effective Myocardial Protection Time of Del Nido Cardioplegia in Adult Cardiac Surgery","status":"RECRUITING","sponsor":"Muhammet Talha Ceran, MD","startDate":"2025-11-12","conditions":"Heart Valve Diseases, Aortic Diseases, Myocardial Ischemia","enrollment":80},{"nctId":"NCT04094168","phase":"PHASE4","title":"Clinical Impact of Del Nido Cardioplegia in Adult Cardiac Surgery","status":"COMPLETED","sponsor":"JESSICA GARCIA SUAREZ","startDate":"2018-06-15","conditions":"Heart; Surgery, Heart, Functional Disturbance as Result","enrollment":474},{"nctId":"NCT04259515","phase":"PHASE4","title":"Buckberg vs Del Nido in Isolated Aortic Valve Replacement","status":"COMPLETED","sponsor":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","startDate":"2019-07-16","conditions":"Cardiac Surgical Procedures","enrollment":286},{"nctId":"NCT06744088","phase":"","title":"Clinical Outcomes Of Modified Del Nido Cardioplegia In Adult And Pediatric Cardiac Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Superior University","startDate":"2024-02-28","conditions":"Cardiac Events","enrollment":200},{"nctId":"NCT06683872","phase":"","title":"Evaluation of Clinical Efficacy and Prognosis in Patients with Hypertrophic Obstructive Cardiomyopathy Through Hemodynamic Modeling Reconstructed by CT","status":"ENROLLING_BY_INVITATION","sponsor":"Zhejiang Provincial People's Hospital","startDate":"2024-08-01","conditions":"Hypertrophic Cardiomyopathy (HCM)","enrollment":200},{"nctId":"NCT05298618","phase":"","title":"Magnesium Administration After Cardioplegic Arrest With Del Nido Cardioplegia","status":"COMPLETED","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2022-01-24","conditions":"Del Nido Cardioplegia","enrollment":152},{"nctId":"NCT06373549","phase":"","title":"Investigation of Myocardial Protection Efficacy of Cardioplegia Solutions Used in Open Heart Surgery","status":"COMPLETED","sponsor":"Tamer cebe","startDate":"2022-12-08","conditions":"Cardiovascular Diseases, Myocardial Reperfusion Injury","enrollment":2},{"nctId":"NCT04051580","phase":"NA","title":"Comparison of Lactated Ringer's Solution and PlasmaLyte-A as a Base Solution for Del Nido Cardioplegia","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2019-08-05","conditions":"Myocardial Injury","enrollment":200},{"nctId":"NCT06235424","phase":"PHASE4","title":"Del Nido Versus HTK Cardioplegia in Adult Aortic Valve Replacement","status":"UNKNOWN","sponsor":"Medical University of Gdansk","startDate":"2018-10-01","conditions":"Aortic Valve Disease, Valve Disease, Heart, Cardiac Ischemia","enrollment":100},{"nctId":"NCT05221294","phase":"NA","title":"Modified Del Nido Versus Custodiol Cardioplegia For Myocardial Protection In Cardiac Surgery.","status":"COMPLETED","sponsor":"Fayoum University Hospital","startDate":"2022-02-01","conditions":"Cardioplegia Solution Adverse Reaction","enrollment":58},{"nctId":"NCT05603429","phase":"","title":"Investigation of Myocardial Protection Level With Specific Cardioplegia Methods in Cardiac Surgery","status":"COMPLETED","sponsor":"Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital","startDate":"2022-10-13","conditions":"Bypass Complication, Cardioplegia Solution Adverse Reaction, Endothelial Degeneration","enrollment":74},{"nctId":"NCT05797090","phase":"NA","title":"Comparative Study Between Conventional Crystalloid Cardioplegic Solution With Modified Del Nido Cardioplegia","status":"COMPLETED","sponsor":"mohamed","startDate":"2022-07-01","conditions":"Mitral Valve Surgery","enrollment":80},{"nctId":"NCT02442050","phase":"NA","title":"Del Nido Cardioplegia Randomized Trial","status":"TERMINATED","sponsor":"Inova Health Care Services","startDate":"2015-01","conditions":"Cardiac Perfusion","enrollment":99},{"nctId":"NCT03818126","phase":"NA","title":"The Del Nido Versus Cold Blood Cardioplegia in Aortic Valve Replacement","status":"COMPLETED","sponsor":"Pawel Buszman","startDate":"2016-07-01","conditions":"Aortic Valve Disease, Ischemia-reperfusion Injury","enrollment":150},{"nctId":"NCT02646254","phase":"PHASE4","title":"Myocardial Protection and Clinical Outcome in Patients Undergoing Tetralogy of Fallot Repair : A Randomized Study of Two Different Cardioplegia Technique","status":"COMPLETED","sponsor":"SUNDER LAL NEGI","startDate":"2014-06","conditions":"Myocardial Protection in TOF Repair","enrollment":56}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":316,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Del Nido","genericName":"Del Nido","companyName":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","companyId":"fundaci-institut-de-recerca-de-l-hospital-de-la-santa-creu-i-sant-pau","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Del Nido cardioplegia is a cold crystalloid solution that rapidly cools and arrests the heart during cardiac surgery by delivering potassium and other electrolytes to stop myocardial contractions. Used for Myocardial protection during cardiac surgery requiring cardiopulmonary bypass.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}