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Dapsone; Tretinoin
This combination of dapsone (an antimicrobial and anti-inflammatory agent) and tretinoin (a retinoid that promotes skin cell turnover) works synergistically to reduce inflammation and normalize skin cell differentiation in acne and rosacea.
This combination of dapsone (an antimicrobial and anti-inflammatory agent) and tretinoin (a retinoid that promotes skin cell turnover) works synergistically to reduce inflammation and normalize skin cell differentiation in acne and rosacea. Used for Acne vulgaris, Rosacea.
At a glance
| Generic name | Dapsone; Tretinoin |
|---|---|
| Also known as | Aczone Gel 5%; Tretin-X Gel 0.025% |
| Sponsor | Allergan |
| Drug class | Antimicrobial/retinoid combination |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Dapsone suppresses neutrophil function and reduces inflammatory mediators, while tretinoin increases epidermal cell turnover and reduces comedone formation. Together, they address both the inflammatory and comedonal components of acne. This combination is marketed as Aczone (dapsone gel) with tretinoin co-prescription or as a fixed combination for enhanced efficacy in treating inflammatory acne.
Approved indications
- Acne vulgaris
- Rosacea
Common side effects
- Dryness and peeling
- Erythema and irritation
- Photosensitivity
- Hemolytic anemia (dapsone-related, rare)
Key clinical trials
- A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products (PHASE4)
- Dapsone Gel 5% and Tretinoin Gel 0.025% Versus Tretinoin Gel 0.025% Monotherapy for Facial Acne Vulgaris (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dapsone; Tretinoin CI brief — competitive landscape report
- Dapsone; Tretinoin updates RSS · CI watch RSS
- Allergan portfolio CI