{"id":"dapsone-tretinoin","safety":{"commonSideEffects":[{"rate":null,"effect":"Dryness and peeling"},{"rate":null,"effect":"Erythema and irritation"},{"rate":null,"effect":"Photosensitivity"},{"rate":"<1%","effect":"Hemolytic anemia (dapsone-related, rare)"}]},"_chembl":null,"_dailymed":{"setId":"88011b04-0617-48ad-e053-2a95a90aa384","title":"DAPSONE 6% / NIACINAMIDE 2% / TRETINOIN 0.025% GEL [SINCERUS FLORIDA, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dapsone suppresses neutrophil function and reduces inflammatory mediators, while tretinoin increases epidermal cell turnover and reduces comedone formation. Together, they address both the inflammatory and comedonal components of acne. This combination is marketed as Aczone (dapsone gel) with tretinoin co-prescription or as a fixed combination for enhanced efficacy in treating inflammatory acne.","oneSentence":"This combination of dapsone (an antimicrobial and anti-inflammatory agent) and tretinoin (a retinoid that promotes skin cell turnover) works synergistically to reduce inflammation and normalize skin cell differentiation in acne and rosacea.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:32:12.893Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"},{"name":"Rosacea"}]},"trialDetails":[{"nctId":"NCT01313728","phase":"PHASE4","title":"A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2010-12","conditions":"Acne Vulgaris","enrollment":26},{"nctId":"NCT00835198","phase":"PHASE4","title":"Dapsone Gel 5% and Tretinoin Gel 0.025% Versus Tretinoin Gel 0.025% Monotherapy for Facial Acne Vulgaris","status":"COMPLETED","sponsor":"Allergan","startDate":"2008-12","conditions":"Acne Vulgaris","enrollment":163}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Aczone Gel 5%; Tretin-X Gel 0.025%"],"phase":"marketed","status":"active","brandName":"Dapsone; Tretinoin","genericName":"Dapsone; Tretinoin","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination of dapsone (an antimicrobial and anti-inflammatory agent) and tretinoin (a retinoid that promotes skin cell turnover) works synergistically to reduce inflammation and normalize skin cell differentiation in acne and rosacea. Used for Acne vulgaris, Rosacea.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}