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Dapsone Topical Gel + adapalene gel 0.1%

Allergan · Phase 3 active Small molecule

Dapsone Topical Gel + adapalene gel 0.1% is a Combination topical antimicrobial and retinoid Small molecule drug developed by Allergan. It is currently in Phase 3 development for Acne vulgaris.

Dapsone provides antimicrobial and anti-inflammatory effects while adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation.

Dapsone provides antimicrobial and anti-inflammatory effects while adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation. Used for Acne vulgaris.

At a glance

Generic nameDapsone Topical Gel + adapalene gel 0.1%
SponsorAllergan
Drug classCombination topical antimicrobial and retinoid
TargetRetinoic acid receptor (adapalene); dihydropteroate synthase inhibition (dapsone)
ModalitySmall molecule
Therapeutic areaDermatology
PhasePhase 3

Mechanism of action

Dapsone acts as a sulfone antimicrobial agent with immunomodulatory properties, suppressing neutrophil function and reducing inflammatory mediators. Adapalene is a third-generation retinoid that binds to retinoic acid receptors, promoting cell turnover and reducing comedone formation. Together, the combination targets both bacterial and inflammatory components of acne.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Dapsone Topical Gel + adapalene gel 0.1%

What is Dapsone Topical Gel + adapalene gel 0.1%?

Dapsone Topical Gel + adapalene gel 0.1% is a Combination topical antimicrobial and retinoid drug developed by Allergan, indicated for Acne vulgaris.

How does Dapsone Topical Gel + adapalene gel 0.1% work?

Dapsone provides antimicrobial and anti-inflammatory effects while adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation.

What is Dapsone Topical Gel + adapalene gel 0.1% used for?

Dapsone Topical Gel + adapalene gel 0.1% is indicated for Acne vulgaris.

Who makes Dapsone Topical Gel + adapalene gel 0.1%?

Dapsone Topical Gel + adapalene gel 0.1% is developed by Allergan (see full Allergan pipeline at /company/allergan).

What drug class is Dapsone Topical Gel + adapalene gel 0.1% in?

Dapsone Topical Gel + adapalene gel 0.1% belongs to the Combination topical antimicrobial and retinoid class. See all Combination topical antimicrobial and retinoid drugs at /class/combination-topical-antimicrobial-and-retinoid.

What development phase is Dapsone Topical Gel + adapalene gel 0.1% in?

Dapsone Topical Gel + adapalene gel 0.1% is in Phase 3.

What are the side effects of Dapsone Topical Gel + adapalene gel 0.1%?

Common side effects of Dapsone Topical Gel + adapalene gel 0.1% include Erythema, Dryness, Peeling, Irritation, Photosensitivity.

What does Dapsone Topical Gel + adapalene gel 0.1% target?

Dapsone Topical Gel + adapalene gel 0.1% targets Retinoic acid receptor (adapalene); dihydropteroate synthase inhibition (dapsone) and is a Combination topical antimicrobial and retinoid.

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