{"id":"dapsone-topical-gel-adapalene-gel-0-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Peeling"},{"rate":null,"effect":"Irritation"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL1265","moleculeType":"Small molecule","molecularWeight":"412.53"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dapsone acts as a sulfone antimicrobial agent with immunomodulatory properties, suppressing neutrophil function and reducing inflammatory mediators. Adapalene is a third-generation retinoid that binds to retinoic acid receptors, promoting cell turnover and reducing comedone formation. Together, the combination targets both bacterial and inflammatory components of acne.","oneSentence":"Dapsone provides antimicrobial and anti-inflammatory effects while adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:08:37.369Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT00151541","phase":"PHASE3","title":"A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination With Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4%","status":"COMPLETED","sponsor":"Allergan","startDate":"2005-02","conditions":"Acne Vulgaris","enrollment":301}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Dapsone Topical Gel + adapalene gel 0.1%","genericName":"Dapsone Topical Gel + adapalene gel 0.1%","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dapsone provides antimicrobial and anti-inflammatory effects while adapalene is a retinoid that normalizes skin cell differentiation and reduces inflammation. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}