Last reviewed 2026-04-22 · How we verify

Dapsone plus Adapalene

Dapsone reduces inflammation and bacterial growth while adapalene normalizes skin cell turnover and reduces sebum production, together targeting acne pathogenesis.

Dapsone reduces inflammation and bacterial growth while adapalene normalizes skin cell turnover and reduces sebum production, together targeting acne pathogenesis. Used for Acne vulgaris.

At a glance

Mechanism of action

Dapsone is a sulfone antibiotic with anti-inflammatory properties that inhibits neutrophil function and has mild antimicrobial activity against Cutibacterium acnes. Adapalene is a third-generation retinoid that binds retinoic acid receptors to normalize keratinization, reduce comedone formation, and decrease sebaceous gland activity. The combination addresses multiple acne pathogenic factors: inflammation, bacterial colonization, and follicular obstruction.

Approved indications

• Acne vulgaris

Common side effects

• Erythema
• Dryness
• Peeling
• Irritation
• Photosensitivity

Key clinical trials

• Effect of New Topical Preparation for Treatment of Acne Vulgaris (PHASE2)
• A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne (PHASE4)
• A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination With Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4% (PHASE3)

Primary sources

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