{"id":"dapsone-plus-adapalene","safety":{"commonSideEffects":[{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Peeling"},{"rate":null,"effect":"Irritation"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL1265","moleculeType":"Small molecule","molecularWeight":"412.53"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dapsone is a sulfone antibiotic with anti-inflammatory properties that inhibits neutrophil function and has mild antimicrobial activity against Cutibacterium acnes. Adapalene is a third-generation retinoid that binds retinoic acid receptors to normalize keratinization, reduce comedone formation, and decrease sebaceous gland activity. The combination addresses multiple acne pathogenic factors: inflammation, bacterial colonization, and follicular obstruction.","oneSentence":"Dapsone reduces inflammation and bacterial growth while adapalene normalizes skin cell turnover and reduces sebum production, together targeting acne pathogenesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:32:02.642Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT05899699","phase":"PHASE2","title":"Effect of New Topical Preparation for Treatment of Acne Vulgaris","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2023-06-05","conditions":"Acne Vulgaris","enrollment":20},{"nctId":"NCT01231334","phase":"PHASE4","title":"A Study Comparing Aczone® Plus Differin® Versus Duac® Plus Differin® in Patients With Severe Facial Acne","status":"COMPLETED","sponsor":"Allergan","startDate":"2010-08","conditions":"Acne Vulgaris","enrollment":286},{"nctId":"NCT00151541","phase":"PHASE3","title":"A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination With Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4%","status":"COMPLETED","sponsor":"Allergan","startDate":"2005-02","conditions":"Acne Vulgaris","enrollment":301}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Aczone® Gel 5%","Differin® 0.3% Gel"],"phase":"marketed","status":"active","brandName":"Dapsone plus Adapalene","genericName":"Dapsone plus Adapalene","companyName":"Allergan","companyId":"allergan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dapsone reduces inflammation and bacterial growth while adapalene normalizes skin cell turnover and reduces sebum production, together targeting acne pathogenesis. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}