What is CYB004 used for?

CYB004 is indicated for Treatment-resistant depression.

CYB004 is developed by Cybin IRL Limited.

What are the side effects of CYB004?

Common side effects include Increased heart rate, Anxiety, Hallucinations.

Last reviewed 2026-04-23 · How we verify

CYB004

Cybin IRL Limited · Phase 2 active Small molecule

CYB004 is a psychedelic compound that acts as a serotonin 5-HT2A receptor agonist.

CYB004 is a psychedelic compound that acts as a serotonin 5-HT2A receptor agonist. Used for Treatment-resistant depression.

At a glance

Generic name	CYB004
Sponsor	Cybin IRL Limited
Drug class	Serotonin 5-HT2A receptor agonist
Target	5-HT2A
Modality	Small molecule
Therapeutic area	Psychiatry
Phase	Phase 2

Mechanism of action

Serotonin 5-HT2A receptor agonists, such as CYB004, are known to induce altered states of consciousness and have been studied for their potential therapeutic applications in treating various mental health conditions.

Approved indications

Treatment-resistant depression

Common side effects

Increased heart rate
Anxiety
Hallucinations

Key clinical trials

A Study of a N, N-dimethyltryptamine (DMT) Analog (CYB004) in Participants With Generalized Anxiety Disorder (GAD) (PHASE2)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

CYB004 CI brief — competitive landscape report
CYB004 updates RSS · CI watch RSS
Cybin IRL Limited portfolio CI