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Cryotherapy + Tirbanibulin

University Hospital, Lille · Phase 3 active Small molecule

Cryotherapy physically destroys actinic keratosis lesions through freezing, while tirbanibulin is a non-steroidal topical agent that induces keratinocyte apoptosis to treat actinic keratosis.

Cryotherapy physically destroys actinic keratosis lesions through freezing, while tirbanibulin is a non-steroidal topical agent that induces keratinocyte apoptosis to treat actinic keratosis. Used for Actinic keratosis.

At a glance

Generic nameCryotherapy + Tirbanibulin
Also known asCryotherapy + placebo
SponsorUniversity Hospital, Lille
Drug classCombination therapy: cryotherapy + Src kinase inhibitor
TargetSrc kinase (tirbanibulin component)
ModalitySmall molecule
Therapeutic areaDermatology/Oncology
PhasePhase 3

Mechanism of action

This combination approach uses cryotherapy (liquid nitrogen freezing) to ablate visible actinic keratosis lesions, followed by tirbanibulin application to target remaining or subclinical lesions. Tirbanibulin is a Src kinase inhibitor that promotes apoptosis in dysplastic keratinocytes. The dual mechanism addresses both clinical and subclinical disease.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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