{"id":"cryotherapy-tirbanibulin","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation (erythema, scaling)"},{"rate":null,"effect":"Pain or discomfort at treatment site"},{"rate":null,"effect":"Cryotherapy-induced blistering or crusting"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination approach uses cryotherapy (liquid nitrogen freezing) to ablate visible actinic keratosis lesions, followed by tirbanibulin application to target remaining or subclinical lesions. Tirbanibulin is a Src kinase inhibitor that promotes apoptosis in dysplastic keratinocytes. The dual mechanism addresses both clinical and subclinical disease.","oneSentence":"Cryotherapy physically destroys actinic keratosis lesions through freezing, while tirbanibulin is a non-steroidal topical agent that induces keratinocyte apoptosis to treat actinic keratosis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:07:58.255Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis"}]},"trialDetails":[{"nctId":"NCT07273656","phase":"PHASE3","title":"Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Lille","startDate":"2025-11-30","conditions":"Keratosis, Actinic Keratoses","enrollment":59}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cryotherapy + placebo"],"phase":"phase_3","status":"active","brandName":"Cryotherapy + Tirbanibulin","genericName":"Cryotherapy + Tirbanibulin","companyName":"University Hospital, Lille","companyId":"university-hospital-lille","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cryotherapy physically destroys actinic keratosis lesions through freezing, while tirbanibulin is a non-steroidal topical agent that induces keratinocyte apoptosis to treat actinic keratosis. Used for Actinic keratosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}