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Crataegus Special Extract WS 1442

National Center for Complementary and Integrative Health (NCCIH) · Phase 3 active Small molecule

Crataegus Special Extract WS 1442 is a Botanical extract / Herbal preparation Small molecule drug developed by National Center for Complementary and Integrative Health (NCCIH). It is currently in Phase 3 development for Chronic heart failure (NYHA functional class II), Cardiac insufficiency.

Crataegus WS 1442 is a standardized hawthorn extract that improves cardiac function and blood flow by enhancing myocardial contractility and reducing peripheral vascular resistance.

Crataegus WS 1442 is a standardized hawthorn extract that improves cardiac function and blood flow by enhancing myocardial contractility and reducing peripheral vascular resistance. Used for Chronic heart failure (NYHA functional class II), Cardiac insufficiency.

At a glance

Generic nameCrataegus Special Extract WS 1442
SponsorNational Center for Complementary and Integrative Health (NCCIH)
Drug classBotanical extract / Herbal preparation
ModalitySmall molecule
Therapeutic areaCardiovascular
PhasePhase 3

Mechanism of action

The extract contains flavonoids and oligomeric procyanidins that act as antioxidants and improve energy metabolism in cardiac myocytes. It increases cardiac output and coronary blood flow while reducing afterload, making it beneficial for heart failure management. The mechanism involves positive inotropic effects without the adverse effects associated with traditional inotropic agents.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Crataegus Special Extract WS 1442

What is Crataegus Special Extract WS 1442?

Crataegus Special Extract WS 1442 is a Botanical extract / Herbal preparation drug developed by National Center for Complementary and Integrative Health (NCCIH), indicated for Chronic heart failure (NYHA functional class II), Cardiac insufficiency.

How does Crataegus Special Extract WS 1442 work?

Crataegus WS 1442 is a standardized hawthorn extract that improves cardiac function and blood flow by enhancing myocardial contractility and reducing peripheral vascular resistance.

What is Crataegus Special Extract WS 1442 used for?

Crataegus Special Extract WS 1442 is indicated for Chronic heart failure (NYHA functional class II), Cardiac insufficiency.

Who makes Crataegus Special Extract WS 1442?

Crataegus Special Extract WS 1442 is developed by National Center for Complementary and Integrative Health (NCCIH) (see full National Center for Complementary and Integrative Health (NCCIH) pipeline at /company/national-center-for-complementary-and-integrative-health-nccih).

What drug class is Crataegus Special Extract WS 1442 in?

Crataegus Special Extract WS 1442 belongs to the Botanical extract / Herbal preparation class. See all Botanical extract / Herbal preparation drugs at /class/botanical-extract-herbal-preparation.

What development phase is Crataegus Special Extract WS 1442 in?

Crataegus Special Extract WS 1442 is in Phase 3.

What are the side effects of Crataegus Special Extract WS 1442?

Common side effects of Crataegus Special Extract WS 1442 include Gastrointestinal upset, Dizziness, Fatigue, Headache.

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