{"id":"crataegus-special-extract-ws-1442","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The extract contains flavonoids and oligomeric procyanidins that act as antioxidants and improve energy metabolism in cardiac myocytes. It increases cardiac output and coronary blood flow while reducing afterload, making it beneficial for heart failure management. The mechanism involves positive inotropic effects without the adverse effects associated with traditional inotropic agents.","oneSentence":"Crataegus WS 1442 is a standardized hawthorn extract that improves cardiac function and blood flow by enhancing myocardial contractility and reducing peripheral vascular resistance.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:07:52.117Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic heart failure (NYHA functional class II)"},{"name":"Cardiac insufficiency"}]},"trialDetails":[{"nctId":"NCT00343902","phase":"PHASE3","title":"Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) Trial","status":"COMPLETED","sponsor":"National Center for Complementary and Integrative Health (NCCIH)","startDate":"2000-01","conditions":"Chronic Heart Failure","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Crataegus Special Extract WS 1442","genericName":"Crataegus Special Extract WS 1442","companyName":"National Center for Complementary and Integrative Health (NCCIH)","companyId":"national-center-for-complementary-and-integrative-health-nccih","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Crataegus WS 1442 is a standardized hawthorn extract that improves cardiac function and blood flow by enhancing myocardial contractility and reducing peripheral vascular resistance. Used for Chronic heart failure (NYHA functional class II), Cardiac insufficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}