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Cox2 inhibitor (Celecoxib)

Seoul National University Hospital · FDA-approved active Small molecule

Cox2 inhibitor (Celecoxib) is a COX-2 selective inhibitor (coxib) Small molecule drug developed by Seoul National University Hospital. It is currently FDA-approved for Rheumatoid arthritis, Osteoarthritis, Acute pain. Also known as: Celebrex.

Celecoxib selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of prostaglandins that mediate inflammation and pain.

Celecoxib selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of prostaglandins that mediate inflammation and pain. Used for Rheumatoid arthritis, Osteoarthritis, Acute pain.

At a glance

Generic nameCox2 inhibitor (Celecoxib)
Also known asCelebrex
SponsorSeoul National University Hospital
Drug classCOX-2 selective inhibitor (coxib)
TargetCOX-2 (Cyclooxygenase-2)
ModalitySmall molecule
Therapeutic areaRheumatology / Pain Management
PhaseFDA-approved

Mechanism of action

COX-2 is an inducible enzyme responsible for generating pro-inflammatory prostaglandins at sites of inflammation. By selectively blocking COX-2 while sparing COX-1, celecoxib reduces inflammation and pain with potentially fewer gastrointestinal side effects than non-selective NSAIDs. This selectivity makes it useful for chronic inflammatory conditions while theoretically preserving the protective functions of COX-1-derived prostaglandins in the stomach and kidneys.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about Cox2 inhibitor (Celecoxib)

What is Cox2 inhibitor (Celecoxib)?

Cox2 inhibitor (Celecoxib) is a COX-2 selective inhibitor (coxib) drug developed by Seoul National University Hospital, indicated for Rheumatoid arthritis, Osteoarthritis, Acute pain.

How does Cox2 inhibitor (Celecoxib) work?

Celecoxib selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of prostaglandins that mediate inflammation and pain.

What is Cox2 inhibitor (Celecoxib) used for?

Cox2 inhibitor (Celecoxib) is indicated for Rheumatoid arthritis, Osteoarthritis, Acute pain, Ankylosing spondylitis, Familial adenomatous polyposis (FAP).

Who makes Cox2 inhibitor (Celecoxib)?

Cox2 inhibitor (Celecoxib) is developed and marketed by Seoul National University Hospital (see full Seoul National University Hospital pipeline at /company/seoul-national-university-hospital).

Is Cox2 inhibitor (Celecoxib) also known as anything else?

Cox2 inhibitor (Celecoxib) is also known as Celebrex.

What drug class is Cox2 inhibitor (Celecoxib) in?

Cox2 inhibitor (Celecoxib) belongs to the COX-2 selective inhibitor (coxib) class. See all COX-2 selective inhibitor (coxib) drugs at /class/cox-2-selective-inhibitor-coxib.

What development phase is Cox2 inhibitor (Celecoxib) in?

Cox2 inhibitor (Celecoxib) is FDA-approved (marketed).

What are the side effects of Cox2 inhibitor (Celecoxib)?

Common side effects of Cox2 inhibitor (Celecoxib) include Hypertension, Dyspepsia, Abdominal pain, Diarrhea, Headache, Cardiovascular events (myocardial infarction, stroke).

What does Cox2 inhibitor (Celecoxib) target?

Cox2 inhibitor (Celecoxib) targets COX-2 (Cyclooxygenase-2) and is a COX-2 selective inhibitor (coxib).

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