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Coumarin/troxerutin
Coumarin/troxerutin is a bioflavonoid combination that strengthens blood vessel walls and reduces capillary fragility through antioxidant and venoprotective effects.
Coumarin/troxerutin is a bioflavonoid combination that strengthens blood vessel walls and reduces capillary fragility through antioxidant and venoprotective effects. Used for Chronic venous insufficiency, Lymphedema, Hemorrhoids.
At a glance
| Generic name | Coumarin/troxerutin |
|---|---|
| Also known as | Venalot® |
| Sponsor | Takeda |
| Drug class | Venoprotective agent / Bioflavonoid combination |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular / Vascular |
| Phase | FDA-approved |
Mechanism of action
Troxerutin, a semisynthetic flavonoid derivative, works synergistically with coumarin to improve microcirculation and reduce vascular permeability. The combination enhances endothelial function and reduces inflammatory responses in blood vessels, thereby improving venous tone and reducing edema. These agents are used primarily for their venoprotective and lymphoprotective properties in chronic venous insufficiency.
Approved indications
- Chronic venous insufficiency
- Lymphedema
- Hemorrhoids
- Varicose veins
Common side effects
- Gastrointestinal disturbances
- Headache
- Dizziness
- Rash
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |