{"id":"coumarin-troxerutin","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Troxerutin, a semisynthetic flavonoid derivative, works synergistically with coumarin to improve microcirculation and reduce vascular permeability. The combination enhances endothelial function and reduces inflammatory responses in blood vessels, thereby improving venous tone and reducing edema. These agents are used primarily for their venoprotective and lymphoprotective properties in chronic venous insufficiency.","oneSentence":"Coumarin/troxerutin is a bioflavonoid combination that strengthens blood vessel walls and reduces capillary fragility through antioxidant and venoprotective effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:43:57.729Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic venous insufficiency"},{"name":"Lymphedema"},{"name":"Hemorrhoids"},{"name":"Varicose veins"}]},"trialDetails":[{"nctId":"NCT01848210","phase":"PHASE4","title":"Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency","status":"COMPLETED","sponsor":"Takeda","startDate":"2013-05","conditions":"Chronic Venous Insufficiency","enrollment":829}],"_emaApprovals":[],"_faersSignals":[{"count":5,"reaction":"FATIGUE"},{"count":5,"reaction":"MALAISE"},{"count":5,"reaction":"VOMITING"},{"count":4,"reaction":"ABDOMINAL PAIN"},{"count":4,"reaction":"PAIN"},{"count":4,"reaction":"PAIN IN EXTREMITY"},{"count":3,"reaction":"BLOOD PRESSURE INCREASED"},{"count":3,"reaction":"CARDIOVASCULAR DISORDER"},{"count":3,"reaction":"DIARRHOEA"},{"count":3,"reaction":"DRUG INEFFECTIVE"}],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Venalot®"],"phase":"marketed","status":"active","brandName":"Coumarin/troxerutin","genericName":"Coumarin/troxerutin","companyName":"Takeda","companyId":"takeda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Coumarin/troxerutin is a bioflavonoid combination that strengthens blood vessel walls and reduces capillary fragility through antioxidant and venoprotective effects. Used for Chronic venous insufficiency, Lymphedema, Hemorrhoids.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}