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Conventional 24-week glucocorticoid regimen
Glucocorticoids suppress immune and inflammatory responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
Glucocorticoids suppress immune and inflammatory responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Inflammatory and autoimmune conditions requiring sustained immunosuppression (specific indication not detailed in source).
At a glance
| Generic name | Conventional 24-week glucocorticoid regimen |
|---|---|
| Sponsor | First Affiliated Hospital of Wenzhou Medical University |
| Drug class | Glucocorticoid |
| Target | Glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Immunology / Rheumatology / Inflammatory diseases |
| Phase | FDA-approved |
Mechanism of action
Conventional glucocorticoid regimens work by activating intracellular glucocorticoid receptors, which translocate to the nucleus and modulate gene expression to reduce inflammation and immune cell activation. Over a 24-week treatment course, this leads to suppression of inflammatory mediators, reduced immune cell proliferation, and decreased vascular permeability. The regimen is typically used in conditions requiring sustained anti-inflammatory or immunosuppressive effects.
Approved indications
- Inflammatory and autoimmune conditions requiring sustained immunosuppression (specific indication not detailed in source)
Common side effects
- Infection (opportunistic or bacterial)
- Hyperglycemia / glucose intolerance
- Osteoporosis / bone loss
- Hypertension
- Cushingoid features
- Mood disturbances / psychiatric effects
Key clinical trials
- Short-term gluCOCOrticoid in Adult STEROID-sensitive Nephrotic Syndrome: The COCO-ASTEROID Study (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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