Short-term vs Conventional Glucocorticoid Therapy for the Treatment of the Initial Episode of Adult Patient With Steroid-sensitive Idiopathic Nephrotic Syndrome

NCT07151456 Phase 4 NOT_YET_RECRUITING

This study will compare a short-term course (12 week) glucocorticoid regimen with the Conventional 24-week regimen as originally proposed by KDIGO. The purpose of the study is to determine a short-term course (12 week) of glucocorticoid decreases the time to first relapse in adults presenting with steroid sensitive nephrotic syndrome.

Details

Lead sponsor	First Affiliated Hospital of Wenzhou Medical University
Phase	Phase 4
Status	NOT_YET_RECRUITING
Enrolment	224
Start date	2026-01
Completion	2029-12

Conditions

• Idiopathic Nephrotic Syndrome

Interventions

• Conventional 24-week glucocorticoid regimen
• short-term course (12 week) glucocorticoid regimen

Primary outcomes

• Relapse — through study completion, an average of 2 years
  Relapse of proteinuria is defined by Albustix positive proteinuria (+++ or greater) for 3 consecutive days or the presence of generalised oedema plus 3+ proteinuria.

Countries

China