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Continuation of oral anticoagulants
Continuation of oral anticoagulants is a Anticoagulant Small molecule drug developed by St. Antonius Hospital. It is currently FDA-approved for Atrial fibrillation for stroke prevention, Venous thromboembolism (DVT/PE) prevention and treatment, Mechanical heart valve thromboprophylaxis.
Oral anticoagulants prevent blood clot formation by inhibiting coagulation cascade factors, reducing thromboembolism risk.
Oral anticoagulants prevent blood clot formation by inhibiting coagulation cascade factors, reducing thromboembolism risk. Used for Atrial fibrillation for stroke prevention, Venous thromboembolism (DVT/PE) prevention and treatment, Mechanical heart valve thromboprophylaxis.
At a glance
| Generic name | Continuation of oral anticoagulants |
|---|---|
| Sponsor | St. Antonius Hospital |
| Drug class | Anticoagulant |
| Target | Coagulation cascade factors (Factor II, VII, IX, X, or direct Factor Xa/IIa inhibition depending on specific agent) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Oral anticoagulants work through two main classes: vitamin K antagonists (e.g., warfarin) that inhibit factors II, VII, IX, and X, and direct oral anticoagulants (DOACs) that directly inhibit factor Xa or thrombin (factor IIa). Both mechanisms reduce the ability of blood to clot, thereby preventing pathological thrombus formation in conditions prone to thromboembolism.
Approved indications
- Atrial fibrillation for stroke prevention
- Venous thromboembolism (DVT/PE) prevention and treatment
- Mechanical heart valve thromboprophylaxis
- Post-surgical thromboprophylaxis
Common side effects
- Bleeding (major and minor)
- Gastrointestinal bleeding
- Intracranial hemorrhage
- Dyspepsia
Key clinical trials
- OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation (PHASE4)
- CHAMPION-AF Clinical Trial (NA)
- Amplatzer Amulet LAAO vs. NOAC (NA)
- Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation (PHASE4)
- Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation (EARLY_PHASE1)
- Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI) (PHASE4)
- Pill-in-the-POCKET Oral Anticoagulation Strategy After AF Catheter Ablation (NA)
- Rivaroxaban vs. Warfarin for Post Cardiac Surgery Atrial Fibrillation (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Continuation of oral anticoagulants CI brief — competitive landscape report
- Continuation of oral anticoagulants updates RSS · CI watch RSS
- St. Antonius Hospital portfolio CI
Frequently asked questions about Continuation of oral anticoagulants
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Related
- Drug class: All Anticoagulant drugs
- Target: All drugs targeting Coagulation cascade factors (Factor II, VII, IX, X, or direct Factor Xa/IIa inhibition depending on specific agent)
- Manufacturer: St. Antonius Hospital — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Atrial fibrillation for stroke prevention
- Indication: Drugs for Venous thromboembolism (DVT/PE) prevention and treatment
- Indication: Drugs for Mechanical heart valve thromboprophylaxis
- Compare: Continuation of oral anticoagulants vs similar drugs
- Pricing: Continuation of oral anticoagulants cost, discount & access