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Combined Acetaminophen and Ibuprofen
This combination drug reduces pain and fever by inhibiting cyclooxygenase enzymes (via ibuprofen) and modulating central pain pathways (via acetaminophen) simultaneously.
This combination drug reduces pain and fever by inhibiting cyclooxygenase enzymes (via ibuprofen) and modulating central pain pathways (via acetaminophen) simultaneously. Used for Acute pain management, Fever reduction.
At a glance
| Generic name | Combined Acetaminophen and Ibuprofen |
|---|---|
| Also known as | Combined regimen |
| Sponsor | Washington University School of Medicine |
| Drug class | Fixed-dose combination analgesic/antipyretic |
| Target | COX-1, COX-2 (ibuprofen component); unclear central target (acetaminophen component) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Acetaminophen and ibuprofen work through complementary mechanisms: ibuprofen is a non-selective COX inhibitor that reduces prostaglandin synthesis peripherally and centrally, while acetaminophen's exact mechanism remains incompletely understood but involves central nervous system pain modulation and possible COX-3 inhibition. The combination may provide enhanced analgesic and antipyretic effects with potentially lower individual doses of each agent.
Approved indications
- Acute pain management
- Fever reduction
Common side effects
- Gastrointestinal upset
- Nausea
- Dyspepsia
- Hepatotoxicity risk (acetaminophen component)
Key clinical trials
- Study of the Contribution of Osteopathic Treatment to Classic Medical Management in Patients With Chronic Low Back Pain (NA)
- Opioid Analgesic Reduction Study (PHASE3)
- Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants (PHASE2)
- Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children (PHASE3)
- A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain (PHASE3)
- Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat (QuEST1) (PHASE1, PHASE2)
- Preemptive and Preventive Acetaminophen/Ibuprofen Fixed-dose Combination After Robot-assisted Radical Prostatectomy (NA)
- Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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