{"id":"combined-acetaminophen-and-ibuprofen","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Hepatotoxicity risk (acetaminophen component)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acetaminophen and ibuprofen work through complementary mechanisms: ibuprofen is a non-selective COX inhibitor that reduces prostaglandin synthesis peripherally and centrally, while acetaminophen's exact mechanism remains incompletely understood but involves central nervous system pain modulation and possible COX-3 inhibition. 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