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Combination of dexamethasone + dexmedetomidine
Combination of dexamethasone + dexmedetomidine is a Corticosteroid + alpha-2 adrenergic agonist combination Small molecule drug developed by Al-Azhar University. It is currently in Phase 3 development for Perioperative sedation and analgesia (Phase 3 investigational), Reduction of postoperative inflammation and delirium (Phase 3 investigational).
This combination uses dexamethasone (a corticosteroid) to reduce inflammation and dexmedetomidine (an alpha-2 agonist) to provide sedation and analgesia, working synergistically for perioperative or critical care management.
This combination uses dexamethasone (a corticosteroid) to reduce inflammation and dexmedetomidine (an alpha-2 agonist) to provide sedation and analgesia, working synergistically for perioperative or critical care management. Used for Perioperative sedation and analgesia (Phase 3 investigational), Reduction of postoperative inflammation and delirium (Phase 3 investigational).
At a glance
| Generic name | Combination of dexamethasone + dexmedetomidine |
|---|---|
| Sponsor | Al-Azhar University |
| Drug class | Corticosteroid + alpha-2 adrenergic agonist combination |
| Target | Glucocorticoid receptor (dexamethasone); alpha-2A adrenergic receptor (dexmedetomidine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Critical Care, Perioperative Medicine |
| Phase | Phase 3 |
Mechanism of action
Dexamethasone suppresses inflammatory responses and immune activation through glucocorticoid receptor binding, reducing cytokine production and edema. Dexmedetomidine acts as a selective alpha-2 adrenergic agonist in the central nervous system, providing sedation, analgesia, and anxiolysis while maintaining airway reflexes. Together, they may reduce perioperative stress response and improve patient outcomes in surgical or intensive care settings.
Approved indications
- Perioperative sedation and analgesia (Phase 3 investigational)
- Reduction of postoperative inflammation and delirium (Phase 3 investigational)
Common side effects
- Hypotension
- Bradycardia
- Hyperglycemia
- Sedation/drowsiness
- Dry mouth
Key clinical trials
- PENG Block Variants With Dexamethasone and Dexmedetomidine in Older Adults (NA)
- Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks (PHASE1, PHASE2)
- Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA (NA)
- Dexamethasone vs Dexmedetomidine vs Combination as Adjuvants to Popliteal Sciatic Nerve Block in Children (NA)
- Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block (PHASE4)
- Dexamethasone, Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Combination of dexamethasone + dexmedetomidine CI brief — competitive landscape report
- Combination of dexamethasone + dexmedetomidine updates RSS · CI watch RSS
- Al-Azhar University portfolio CI
Frequently asked questions about Combination of dexamethasone + dexmedetomidine
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Related
- Drug class: All Corticosteroid + alpha-2 adrenergic agonist combination drugs
- Target: All drugs targeting Glucocorticoid receptor (dexamethasone); alpha-2A adrenergic receptor (dexmedetomidine)
- Manufacturer: Al-Azhar University — full pipeline
- Therapeutic area: All drugs in Anesthesia, Critical Care, Perioperative Medicine
- Indication: Drugs for Perioperative sedation and analgesia (Phase 3 investigational)
- Indication: Drugs for Reduction of postoperative inflammation and delirium (Phase 3 investigational)
- Compare: Combination of dexamethasone + dexmedetomidine vs similar drugs
- Pricing: Combination of dexamethasone + dexmedetomidine cost, discount & access