{"id":"combination-of-dexamethasone-dexmedetomidine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Sedation/drowsiness"},{"rate":null,"effect":"Dry mouth"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexamethasone suppresses inflammatory responses and immune activation through glucocorticoid receptor binding, reducing cytokine production and edema. Dexmedetomidine acts as a selective alpha-2 adrenergic agonist in the central nervous system, providing sedation, analgesia, and anxiolysis while maintaining airway reflexes. Together, they may reduce perioperative stress response and improve patient outcomes in surgical or intensive care settings.","oneSentence":"This combination uses dexamethasone (a corticosteroid) to reduce inflammation and dexmedetomidine (an alpha-2 agonist) to provide sedation and analgesia, working synergistically for perioperative or critical care management.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:06:44.127Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative sedation and analgesia (Phase 3 investigational)"},{"name":"Reduction of postoperative inflammation and delirium (Phase 3 investigational)"}]},"trialDetails":[{"nctId":"NCT07327931","phase":"NA","title":"PENG Block Variants With Dexamethasone and Dexmedetomidine in Older Adults","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-13","conditions":"Hip Osteoarthritis, Hip Pain Chronic","enrollment":120},{"nctId":"NCT07330999","phase":"NA","title":"Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-13","conditions":"Hip Osteoarthritis","enrollment":120},{"nctId":"NCT07337135","phase":"NA","title":"Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital dos Lusíadas","startDate":"2023-10-02","conditions":"Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia","enrollment":60},{"nctId":"NCT07099222","phase":"PHASE1, PHASE2","title":"Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Arizona","startDate":"2024-10-10","conditions":"Postoperative Pain, Nausea and Vomiting, Postoperative, Dizziness","enrollment":100},{"nctId":"NCT07386600","phase":"NA","title":"Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-01-01","conditions":"Knee Osteoarthritis","enrollment":96},{"nctId":"NCT07289620","phase":"NA","title":"Dexamethasone vs Dexmedetomidine vs Combination as Adjuvants to Popliteal Sciatic Nerve Block in Children","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-01-16","conditions":"Ankle Disease, Foot Diseases","enrollment":120},{"nctId":"NCT07299877","phase":"PHASE4","title":"Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block","status":"NOT_YET_RECRUITING","sponsor":"Al-Azhar University","startDate":"2025-12-28","conditions":"Brachial Plexus Blocks","enrollment":75},{"nctId":"NCT07329933","phase":"NA","title":"Dexamethasone, Dexmedetomidine and Their Combination on Post op. GIT Function Measured by I-FFED Score Post Laparoscopic Cholecystectomy","status":"NOT_YET_RECRUITING","sponsor":"Benha University","startDate":"2025-12-15","conditions":"GIT Function, Cholecystectomy, Laparoscopic, Dexamethasone","enrollment":160},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT05988671","phase":"PHASE3","title":"Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2023-08-10","conditions":"Laparoscopic Cholecystectomy, Postoperative Nausea and Vomiting","enrollment":120},{"nctId":"NCT05705128","phase":"PHASE2, PHASE3","title":"Dexmedetomidine in Postoperative Analgesia","status":"ENROLLING_BY_INVITATION","sponsor":"New Valley University","startDate":"2023-08-01","conditions":"Pain Management","enrollment":100},{"nctId":"NCT03643822","phase":"PHASE4","title":"Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain","status":"RECRUITING","sponsor":"Women's College Hospital","startDate":"2020-02-21","conditions":"ACL Injury","enrollment":252},{"nctId":"NCT06658418","phase":"PHASE1","title":"Erector Spinae Plane Block with Dexmedetomidine and Bupivacain Versus Dexamethasone and Bupivacain for Postoperative Analgesia in Patients Undergoing Abdominal Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Loay Gamal","startDate":"2024-11-01","conditions":"Analgesia, Postoperative","enrollment":90},{"nctId":"NCT06601647","phase":"NA","title":"Efficacy of Different Adjuvants With Ropivacaine in Brachial Plexus Block on Anthroscopic Rotator Cuff Repair","status":"NOT_YET_RECRUITING","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2024-09-19","conditions":"Anesthesia","enrollment":120},{"nctId":"NCT03809442","phase":"PHASE4","title":"Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery.","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2019-06-25","conditions":"Postoperative Analgesia","enrollment":116},{"nctId":"NCT04631822","phase":"NA","title":"Comparing Dexamethasone With Dexmedetomidine as Additives to Bupivacaine in Adductor Canal Block for Knee Arthroscopy.","status":"COMPLETED","sponsor":"Rasha Hamed","startDate":"2021-01-01","conditions":"Pain, Postoperative","enrollment":135},{"nctId":"NCT05271721","phase":"NA","title":"Trans-foraminal Lumbar Epidural Injection of Dexmedetomidine Against Magnesium Sulfate When Combined With Dexamethasone in Uni-lateral Lower Limb Radicular Pain. Multi-centeric Comparative Study","status":"COMPLETED","sponsor":"Minia University","startDate":"2022-03-01","conditions":"Chronic Pain","enrollment":90},{"nctId":"NCT04208516","phase":"PHASE4","title":"Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain.","status":"TERMINATED","sponsor":"Jeremy Kearns","startDate":"2021-05-26","conditions":"Postoperative Pain","enrollment":17},{"nctId":"NCT04818749","phase":"PHASE4","title":"Combined Intravenous Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Orthopaedic Surgery of the Foot and Ankle","status":"COMPLETED","sponsor":"Zealand University Hospital","startDate":"2021-06-02","conditions":"Anesthesia, Local","enrollment":120},{"nctId":"NCT05658692","phase":"PHASE4","title":"Platform Adaptive Embedded Trial for Acute Respiratory Distress Syndrome","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2022-10-01","conditions":"Acute Respiratory Distress Syndrome","enrollment":1000},{"nctId":"NCT05484648","phase":"PHASE4","title":"Dexamethasone or Dexmedetomidine as Adjunct in Fascia Iliaca Block During Positioning for Sub-arachnoid Block & Post-operative Analgesia After Femur Neck Fracture Surgery: A Randomized Control Trial","status":"UNKNOWN","sponsor":"Aga Khan University Hospital, Pakistan","startDate":"2023-01-01","conditions":"Post Operative Pain","enrollment":60},{"nctId":"NCT04394481","phase":"PHASE4","title":"Extension of Analgesia by Combined Injection of Dexamethasone and Dexmedetomidine After Arthroscopic Shoulder Surgery","status":"COMPLETED","sponsor":"GCS Ramsay Santé pour l'Enseignement et la Recherche","startDate":"2020-09-28","conditions":"Analgesia","enrollment":122},{"nctId":"NCT04306159","phase":"NA","title":"Application of Rectus Sheath Block based-on Incision in Upper Abdominal Surgery","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Anhui Medical University","startDate":"2020-03-15","conditions":"Opioid Consumption","enrollment":126},{"nctId":"NCT04694105","phase":"NA","title":"Peri-neural Dexmedetomidine Versus Dexamethasone for Supraaclavicular Block Adjuvant to Bupivacaine Supraclavicular Brachial Plexus Block","status":"COMPLETED","sponsor":"Cairo University","startDate":"2018-06-01","conditions":"Brachial Plexus Block","enrollment":42},{"nctId":"NCT02550795","phase":"NA","title":"Dexmedetomidine or Dexmedetomidine Combined With Dexamethasone on Postoperative Nausea and Vomiting in Breast Cancer","status":"COMPLETED","sponsor":"Gachon University Gil Medical Center","startDate":"2015-09","conditions":"Postoperative Nausea and Vomiting","enrollment":150},{"nctId":"NCT03570645","phase":"PHASE4","title":"Comparison of the Duration of Ropivacaine Combined With Dexmedetomidine or Dexamethasone on Paravertebral Block","status":"COMPLETED","sponsor":"China Medical University, China","startDate":"2019-07-12","conditions":"Lung Cancer","enrollment":154},{"nctId":"NCT03270033","phase":"PHASE4","title":"Intravenous Dexmedetomidine, Dexamethasone and Interscalene Block Duration After Arthroscopic Shoulder Surgery","status":"COMPLETED","sponsor":"University of Manitoba","startDate":"2017-09-18","conditions":"Pain, Postoperative, Shoulder Joint Disorder, Ambulatory Surgical Procedures","enrollment":198},{"nctId":"NCT03261921","phase":"PHASE1","title":"Caudal Combination of Dexamethasone and/or Dexmedetomidine to Bupivacaine in Pediatric Hypospadias Surgery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2016-06-05","conditions":"Caudal Block","enrollment":63},{"nctId":"NCT02479581","phase":"PHASE2","title":"The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Xiangya Hospital of Central South University","startDate":"2015-07","conditions":"Valvular Heart Disease","enrollment":226}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Combination of dexamethasone + dexmedetomidine","genericName":"Combination of dexamethasone + dexmedetomidine","companyName":"Al-Azhar University","companyId":"al-azhar-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses dexamethasone (a corticosteroid) to reduce inflammation and dexmedetomidine (an alpha-2 agonist) to provide sedation and analgesia, working synergistically for perioperative or critical care management. Used for Perioperative sedation and analgesia (Phase 3 investigational), Reduction of postoperative inflammation and delirium (Phase 3 investigational).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}