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Colpermin®
Colpermin is a peppermint oil-based formulation that acts as an antispasmodic agent to reduce smooth muscle contractions in the gastrointestinal tract.
Colpermin is a peppermint oil-based formulation that acts as an antispasmodic agent to reduce smooth muscle contractions in the gastrointestinal tract. Used for Irritable bowel syndrome (IBS) with abdominal pain and cramping, Functional gastrointestinal disorders.
At a glance
| Generic name | Colpermin® |
|---|---|
| Also known as | Group C |
| Sponsor | Shiraz University of Medical Sciences |
| Drug class | Herbal antispasmodic |
| Target | Calcium channels (L-type); smooth muscle relaxant |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | Phase 3 |
Mechanism of action
Peppermint oil contains menthol and other volatile compounds that interact with calcium channels and smooth muscle cells in the intestinal wall, reducing spasm and promoting relaxation. This mechanism helps alleviate symptoms associated with irritable bowel syndrome and other functional gastrointestinal disorders by decreasing abnormal muscle contractions.
Approved indications
- Irritable bowel syndrome (IBS) with abdominal pain and cramping
- Functional gastrointestinal disorders
Common side effects
- Heartburn or reflux
- Allergic reactions (rare)
- Mild gastrointestinal upset
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |